Results 91 to 100 of about 46,942 (270)

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Histaminergic system in brain disorders: lessons from the translational approach and future perspectives [PDF]

, 2014
Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention.
A Jucaite, A Lankford, AA Moya-Garcia, AS Ash, BG Neville, C Guindalini, C Gulat-Marnay, C Gulat-Marnay, C Inocente, C Mariottini, Carmem Gottfried, CY Jin, D Bishara, D Mahmood, Diego Baronio, E Gondard, E Zampeli, EG Lundius, EH Schneider, F Benetti, F Naddafi, G Bongers, G Coruzzi, G Griebel, G Oroszi, G Vanni-Mercier, GC Hsieh, GC Hsieh, Geancarlo Zanatta, GM Haig, GM Haig, H Dai, HH Dale, HL Haas, I Bezprozvanny, I Cangioli, IV Tabarean, J Gomez-Ramirez, JA Rojas-Zamorano, JC Schwartz, JI Mobarakeh, JM Arrang, JM Launay, JO Rinne, JP Overington, JS Lin, JW Black, JW Brown, K Iwabuchi, K Karlstedt, K Meskanen, K Unno, Kamila Castro, KE Browman, L Jouan, L Shan, L Shan, LA Linday, LA Linday, LR Hegstrand, M Bhowmik, M McCarthy, M Poyurovsky, M Sundvik, MA Rosales-Reynoso, ME Bardgett, MH Coelho, MI Strakhova, MJ Gemkow, MJ Smit, MM Wong, N Alonso, N Saligrama, OV Anichtchik, P Nowak, P Panula, P Seeman, PG Rossi, PJ Nathan, R Galici, R Galici, R Parmentier, R Seifert, RA Bakker, RA Bond, RA Grove, RB Rosse, RH Weisler, RS Chang, RS Doody, Rudimar Riesgo, S Kotsopoulos, S Mommert, S Nijmeijer, S Nishino, S Nuutinen, S Rios Romenets, S Threlfell, SH Kim, SI Deutsch, SJ Hill, SJ Medhurst, SM Naushad, T Ishizuka, T Kanbayashi, T Masuoka, T Nakamura, T Shimamura, T Simon, T Yamasaki, Taylor Gonchoroski, TV Fernandez, TY Wang, V Bambini-Junior, W Thies, WL Liu, X Ming, Y Xia, YX Tao, Z Wei, ZL Huang   +120 more
core   +2 more sources

Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders

Movement Disorders, EarlyView.
Abstract Background Excessive daytime sleepiness (EDS) is a disabling symptom of Lewy body disorders (LBD). The hypothalamus is a key sleep–wake regulator and is involved in Lewy pathology, but its contribution to EDS in LBD remains unclear. Objectives To use diffusion‐weighted magnetic resonance imaging (MRI) to detect hypothalamic microstructure and ...
Jesse S. Cohen, Hamsanandini Radhakrishnan, Christopher A. Olm, Sandhitsu R. Das, Philip A. Cook, David A. Wolk, Daniel Weintraub, David J. Irwin, Corey T. McMillan   +8 more
wiley   +1 more source

The Efficacy of Bepotastine Besilate Compared With Hydroxyzine Pamoate for Preventing Infusion Reactions to the First Dose of Rituximab in Patients With Non-Hodgkin Lymphoma: Protocol for a Phase II, Double-Blind, Multicenter Randomized Trial

JMIR Research Protocols
BackgroundRituximab, an anti-CD20 monoclonal antibody, can cause infusion reactions (IRs), especially during the initial rituximab infusion therapy.
Yumi Kitahiro, Kazuhiro Yamamoto, Kimikazu Yakushijin, Takeshi Ioroi, Masaaki Tanda, Kotaro Itohara, Tomohiro Omura, Hironobu Minami, Ikuko Yano   +8 more
doaj   +1 more source

The Effects of Histaminergic Agents in the Nucleus ccumbens of Rats in the Elevated Plus-Maze Test of Anxiety [PDF]

Iranian Journal of Psychiatry, 2010
"n Objective: "n The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Ameneh Rezayof, Saba Taheri, Mohammad-Reza Zarrindast   +2 more
doaj  

Omalizumab: opción terapéutica para la urticaria crónica espontánea de difícil control con vasculitis asociada, reporte de tres casos

Biomédica: revista del Instituto Nacional de Salud, 2013
Introducción. Aproximadamente el 50 % de los casos de urticaria crónica no mejoran adecuadamente con las dosis convencionales de antihistamínicos, por lo cual se han planteado múltiples opciones terapéuticas, entre las cuales el omalizumab es una ...
Libia Susana Diez, Liliana María Tamayo, Ricardo Cardona   +2 more
doaj   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

The role of the tachykinin NK1 receptor in airway changes in a mouse model of allergic asthma [PDF]

, 2004
A
De Swert, Katelijne, Joos, Guy, Pauwels, Romain, Tournoy, Kurt   +3 more
core   +2 more sources

Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins

Molecular Nutrition &Food Research, EarlyView.
In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang, Michelle Lee, Erika de Jesus, Katherine Weh, Connor Howard, Henriette Remmer, Amy B. Howell, Laura A. Kresty   +7 more
wiley   +1 more source

Cytokine responses of intraepithelial lymphocytes are regulated by histamine H2 receptor [PDF]

, 2009
Backgrounds. Histamine participates in the immune regulation of several gastrointestinal diseases. However, the effect of histamine on intestinal intraepithelial lymphocytes (IELs), the front line of intestinal mucosal immune system, is not well ...
A Di Sabatino, A Hayday, A Mazzoni, Akira Hishida, B Lagier, C Lundqvist, CA Akdis, CA Akdis, CC Fox, D Montufar-Solis, E Bolton, E Masini, G Barbara, G Caron, G Monteleone, H Cheroutre, H Cheroutre, H Kiyono, HD Lim, HK Takahashi, IJ Elenkov, K Hoshino, K Takahashi, K Tomita, Kosuke Takagaki, L Knutson, L Lefrancois, LB Hough, LB Svendsen, LE Sander, M Jutel, M Kawaguchi, M Watanabe, Mutsuhiro Ikuma, N Osna, N Osna, P Parronchi, R Boismenu, R Leurs, RL Mosley, S Bischoff, S Kapoor, S Matsumoto, S Takamatsu, S Winterkamp, Satoshi Osawa, T Morichika, T Taguchi, T Taguchi, TA Barrett, Takahisa Furuta, Takanori Yamada, WJ Adams, WJ Adams, Y Horio, Y Sonobe, Yasuhiro Takayanagi, Yasushi Hamaya, Yoshiaki Horio   +58 more
core   +1 more source