Results 71 to 80 of about 28,885 (301)

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats [PDF]

, 2016
Bassem Sadek,1 Ali Saad,1 Gniewomir Latacz,2 Kamil Kuder,2 Agnieszka Olejarz,2 Tadeusz Karcz,2 Holger Stark,3 Katarzyna Kieć-Kononowicz2 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates ...
Stark H, Saad A, Sadek B, Olejarz A, Kuder K, Karcz T, Kiec´-Kononowicz K, Latacz G   +7 more
core  

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Papel do receptor ativado por proteinases-2 (par-2) no comportamento de coçar em camundongos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2009.O objetivo do presente estudo foi investigar os possíveis mecanismos e mediadores envolvidos no
Costa, Robson da
core  

The Effects of Histaminergic Agents in the Nucleus Accumbens of Rats in the Elevated Plus-Maze Test of Anxiety

Basic and Clinical Neuroscience, 2010
Introduction/Aims: The nucleus accumbens (NAc) receives histaminergic neurons from tuberomammillary nuclei. There are also reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Mohammad-Reza Zarrindast, Saba Taherid, Ameneh Rezayof   +2 more
doaj   +2 more sources

Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer’s Disease, Parkinson’s Disease, and Autism Spectrum Disorder

Pharmaceuticals
Histamine performs dual roles as an immune regulator and a neurotransmitter in the mammalian brain. The histaminergic system plays a vital role in the regulation of wakefulness, cognition, neuroinflammation, and neurogenesis that are substantially ...
Shilu Deepa Thomas, Sabna Abdalla, Nermin Eissa, Amal Akour, Niraj Kumar Jha, Shreesh Ojha, Bassem Sadek   +6 more
doaj   +1 more source

Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists. [PDF]

PLoS ONE, 2013
BACKGROUND: The histamine-1 receptor (H1R) antagonist ketotifen increased the threshold of discomfort in hypersensitive IBS patients. The use of peripherally restricted and more selective H1R antagonists may further improve treatment possibilities.
Oana I Stanisor, Sophie A van Diest, Zhumei Yu, Olaf Welting, Noor Bekkali, Jing Shi, Wouter J de Jonge, Guy E Boeckxstaens, Rene M van den Wijngaard   +8 more
doaj   +1 more source

Validation of the European Society of Cardiology Ischemic and Bleeding Risk Criteria for Risk Stratification After Endovascular Therapy in Japanese Patients With Lower Extremity Artery Disease

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The European Society of Cardiology (ESC) guidelines for peripheral artery disease recommend antithrombotic strategies based on high ischemic risk (HIR) and high bleeding risk (HBR) criteria. However, their prognostic value in patients with lower extremity artery disease (LEAD) undergoing endovascular therapy (EVT) remains unclear ...
Hirokazu Shimono, Daisuke Kanda, Akihiro Tokushige, Nobuhiro Ito, Yutaro Nomoto, Hiroyuki Tabata, Kenta Ohmure, Takuro Kubozono, Mitsuru Ohishi   +8 more
wiley   +1 more source

Use of histamine H2 receptor antagonists and outcomes in patients with heart failure: a nationwide population-based cohort study [PDF]

, 2018
Kasper Adelborg,1 Jens Sundbøll,1,2 Morten Schmidt,1,3 Hans Erik Bøtker,2 Noel S Weiss,4 Lars Pedersen,1 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of ...
Adelborg K, Schmidt M, Sundbøll J, Bøtker HE, Pedersen L, Weiss NS, Sørensen HT   +6 more
core  

Keynote review: histamine H3 receptor antagonists reach out for the clinic [PDF]

, 2005
Antagonists of the histamine
de Esch, I.J.P.; id_orcid, Sylvain Celanire, Wijtmans, M., Esch, I.J.P. de, Rob Leurs, Celanire, S., Iwan J.P. de Esch, de Esch, I.J.P., Maikel Wijtmans, Talaga, P., Leurs, R., Patrice Talaga   +11 more
core   +1 more source