Histamine and migraine revisited: mechanisms and possible drug targets [PDF]
The Journal of Headache and Pain, 2019 Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm +2 more
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Journal of Pharmacological Sciences, 2005 The second-generation histamine-H1-receptor antagonists, such as epinastine and cetirizine, are used as non-sedating antihistamines for treating allergic symptoms due to their poor ability to penetrate blood-brain barrier.
Junzo Kamei +4 more
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Prophylaxis of anaphylactoid reactions to a polypeptidal plasma substitute by H1- plus H2-receptor antagonists: synopsis of three randomized controlled trials [PDF]
, 1982 To demonstrate the efficacy of a premedication with H1- + H2-receptor antagonists against histamine-release responses in anaesthesia and surgery 3 randomized controlled trials were conducted in patients, volunteers and experimental animals (dogs ...
Lorenz, Wilfried +5 more
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Perioperative uses of histamine antagonists [PDF]
, 1990 Histamine release and adverse pseudoallergic/allergic reactions during the perioperative period occur frequently. The incidence of such reactions is 20%-30% for all grades of severity, 1%-5% for systemic reactions, and 0.1%-0.5% for life-threatening ...
Lorenz, Wilfried +7 more
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Anais Brasileiros de Dermatologia, 2010 As drogas com ação anti-histamínica estão entre as medicações mais comumente prescritas na prática dermatológica diária, tanto em adultos como em crianças.
Paulo Ricardo Criado +3 more
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Incidence and clinical importance of perioperative histamine release: randomised study of volume loading and antihistamines after induction of anaesthesia [PDF]
, 1994 Although histamine release is recognised as a common event during anaesthesia and surgery, few clinicians judge the resultant cardiorespiratory disturbances serious enough to warrant prophylaxis with antihistamines.
Lorenz, Wilfried +10 more
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Could histamine h1 receptor antagonists be used for treating covid-19? [PDF]
, 2021 COVID-19 has rapidly become a pandemic worldwide, causing extensive and long-term health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection and improve the outcome of COVID-19 patients. Unbalanced lung inflammation is a
Changbo Qu +7 more
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Are hypotension and rash after atracurium really caused by histamine release? [PDF]
, 1994 A prospective, randomized, double-blind study was performed in 40 patients (ASA class I-III) treated with atracurium to ascertain whether histamine release caused hemodynamic or cutaneous changes.
Doenicke, A. +4 more
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Perioperative nonspecific histamine release: a new classification by aetiological mechanisms and evaluation of their clinical relevance [PDF]
, 1993 As a consequence of the performance of a randomized controlled clinical trial on perioperative histamine release and cardiovascular and respiratory disturbances, several types of increases in plasma histamine had to be distinguished instead of only two ...
Lorenz, Wilfried +9 more
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Histamine antagonists promote cancer immunosurveillance
, 2023 Recently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype ...
Kepp, Oliver +5 more
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