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Nonsedating histamine H1-receptor antagonists.
Clinical pharmacy, 1989The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosages of the nonsedating histamine H1-receptor antagonists terfenadine, astemizole, loratadine, and acrivastine are reviewed. Terfenadine and astemizole are chemically unrelated to histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine ...
K V, Mann, J P, Crowe, K J, Tietze
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Determination of some histamine H1-receptor antagonists in dosage forms
Journal of Pharmaceutical and Biomedical Analysis, 2002Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with chloroform and subsequently measured ...
Azza A, Gazy +4 more
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Chemistry of Anti-H1 Histamine Antagonists
1978In this Chapter a survey and discussion of the chemistry of compounds which antagonize the effects of histamine at H1 receptors are presented. Ellis (1969) has compiled an extensive list of reviews on histamine, 5-hydroxytryptamine, and their antagonists, several of which include some account of the chemical aspects of antihistaminics.
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A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor
European Journal of Pharmacology, 2007Eosinophilic chemokines and histamine play distinct but important roles in allergic diseases. Inhibition of both eosinophilic chemokines and histamine, therefore, is an ideal strategy for the treatment of allergic inflammation, such as asthma, allergic rhinitis, and atopic dermatitis.
Keiko, Suzuki +7 more
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The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats
Neuroscience Letters, 1997The effect of the histamine H1-receptor antagonist chlorpheniramine on inhibitory avoidance conditioning was investigated in 31-month-old rats, using a one-trial step-through avoidance task. Immediately after the learning trial, old rats were injected intraperitoneally with 5 or 10 mg/kg d-chlorpheniramine.
C, Frisch, R U, Hasenöhrl, J P, Huston
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Agents and Actions, 1973
Histamine methyltransferase from pig antrum mucosa was inhibited by 33 H1-receptor antagonists, by the H2-receptor antagonists burimamide and metiamide and by the burimamide analogue 5-methylburimamide, which did neither act on H1-nor on H2-receptors.
H, Barth, I, Niemeyer, W, Lorenz
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Histamine methyltransferase from pig antrum mucosa was inhibited by 33 H1-receptor antagonists, by the H2-receptor antagonists burimamide and metiamide and by the burimamide analogue 5-methylburimamide, which did neither act on H1-nor on H2-receptors.
H, Barth, I, Niemeyer, W, Lorenz
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The H1-histamine antagonist Dithiaden® inhibits human platelets in vitro
Inflammation Research, 1996Cationic amphiphilic drugs (CAD), including antihistaminics, inhibit platelet aggregation in vitro [1]. We demonstrated recently that Dithiaden® (DIT) antagonised stimulated rat platelets at the level of the arachidonic acid pathway suggesting that phospholipase A2 may be the si te of DIT action [2].
R, Nosál, V, Jancinová, E, Danihelová
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The Use of H1 and H2 Histamine Antagonists with Morphine Anesthesia
Anesthesiology, 1981High doses of morphine can produce significant cardiovascular effects generally attributed to histamine release. The authors examined the possibility that H1 and H2 histamine antagonists might prove beneficial in preventing these responses. In a randomized double-blind study, four groups of 10 patients each received 1 mg/kg morphine and either a ...
D M, Philbin +7 more
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Antagonists of H1 Receptors of Histamine: Recent Developments
1991In the previous handbook of this series on this topic (Casy 1978), attention was drawn to the fact that most compounds known at that time which effectively antagonized histamine at H1-receptor sites could be described by the general structure (1) Open image in new window (1)
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