Results 1 to 10 of about 26,595 (267)

Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells [PDF]

Scientific Reports, 2021
Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is ...
Nobuki Matsumoto, Miku Ebihara, Shiori Oishi, Yuku Fujimoto, Tomoko Okada, Toru Imamura   +5 more
doaj   +4 more sources

Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns [PDF]

Frontiers in Endocrinology, 2023
Severe burns induce a catecholamine surge, causing severe damage to the organism and raising the possibility of multisystem organ failure. Few strategies are generally acceptable to reduce catecholamine surge and organ injury post-burn.
Jizhuang Wang, Chenghao Lu, Xinying Liu, Gai Zhang, Jie Zhang, Min Gao, Dan Liu, Xiong Zhang, Yan Liu   +8 more
doaj   +2 more sources

Histamine H1‐receptor‐mediated modulation of NMDA receptors signaling responses [PDF]

Pharmacology Research & Perspectives
This study attempted to clarify the role of histamine H1 receptors in epilepsy by exploring the effects of agonists and inverse agonists on the rundown of the current induced by iterative applications of NMDA or GABA in primary neuronal culture ...
J.‐M. Arrang, V. Armand
doaj   +2 more sources

Histamine H1-receptors modulate somatostatin receptors coupled to the inhibition of adenylyl cyclase in the rat frontoparietal cortex [PDF]

, 1997
Since exogenous histamine has been previously shown to increase the somatostatin (SS) receptor-effector system in the rat frontoparietal cortex and both histamine H1-receptor agonists and SS modulate higher nervous activity and have anticonvulsive ...
Arilla Ferreiro, Eduardo, Ocaña Fuentes, Aurelio, Puebla Jiménez, Lilian   +2 more
core   +4 more sources

Localization and Upregulation of the Nasal Histamine H1 Receptor in Perennial Allergic Rhinitis [PDF]

Mediators of Inflammation, 2012
In the present study, we have investigated the expression of histamine H1 receptor in human turbinates by RT-PCR, western blotting, and immunohistochemistry.
Hideaki Shirasaki, Etsuko Kanaizumi, Nobuhiko Seki, Tetsuo Himi   +3 more
doaj   +2 more sources

Stimulation of Histamine H1 Receptor Up-Regulates Histamine H1 Receptor Itself Through Activation of Receptor Gene Transcription

Journal of Pharmacological Sciences, 2007
Histamine is a major mediator in allergy acting mainly through the histamine H1 receptor (H1R). Although H1R up-regulation has been suggested as an important step for induction of allergic symptoms, little is known about the regulation of H1R level. Here
Asish K. Das, Sachiho Yoshimura, Ryoko Mishima, Katsumi Fujimoto, Hiroyuki Mizuguchi, Shrabanti Dev, Yousuke Wakayama, Yoshiaki Kitamura, Shuhei Horio, Noriaki Takeda, Hiroyuki Fukui   +10 more
doaj   +4 more sources

Effects of Histamine and H1- and H2-Receptor Blocker on Food Intake, Food Passage Rate and in situ Nutrient Uptake from the Small Intestine of Chicken (Gallus domestics)

The Journal of Poultry Science, 2007
To implicate histamine and its receptors in feed intake and nutrient transport, White Leghorn cockerels of the same age and body weight were grouped randomly into six groups.
Abdul Nasir, Ram P. Moudgal, Narendra B. Singh   +2 more
doaj   +3 more sources

Histamine H1 Receptor Contributes to Vestibular Compensation. [PDF]

J Neurosci, 2019
Vestibular compensation is responsible for the spontaneous recovery of postural, locomotor, and oculomotor dysfunctions in patients with peripheral vestibular lesion or posterior circulation stroke. Mechanism investigation of vestibular compensation is of great importance in both facilitating recovery of vestibular function and understanding the ...
Chen ZP, Zhang XY, Peng SY, Yang ZQ, Wang YB, Zhang YX, Chen X, Wang JJ, Zhu JN.   +8 more
europepmc   +4 more sources

The Impact of H1–H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis [PDF]

Pharmaceuticals
Background/Objectives: The global prevalence and incidence of inflammatory bowel diseases have risen in the past two decades. Among them, Crohn’s disease and ulcerative colitis are still challenging to treat due to vascular and proliferative alterations.
Bartosz Bogielski, Katarzyna Michalczyk, Wojciech Gębski, Katarzyna Rozpędek, Elżbieta Szulińska, Bartosz Tempka, Aleksandra Zorychta, Elżbieta Chełmecka, Ewa Kaczmar, Piotr Głodek, Jakub John, Kamil Nikiel, Bronisława Skrzep-Poloczek, Jerzy Jochem, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Dominika Stygar   +16 more
doaj   +2 more sources

Effects of First- and Second-Generation Histamine-H1-Receptor Antagonists on the Pentobarbital-Induced Loss of the Righting Reflex in Streptozotocin-Induced Diabetic Mice

Journal of Pharmacological Sciences, 2005
The second-generation histamine-H1-receptor antagonists, such as epinastine and cetirizine, are used as non-sedating antihistamines for treating allergic symptoms due to their poor ability to penetrate blood-brain barrier.
Junzo Kamei, Shoko Hirano, Shigeo Miyata, Akiyoshi Saitoh, Kenji Onodera   +4 more
doaj   +3 more sources