Results 101 to 110 of about 26,595 (267)

Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]

open access: yes, 2018
Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core   +2 more sources

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

open access: yes
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Kujin Suppresses Histamine Signaling at the Transcriptional Level in Toluene 2,4-Diisocyanate–Sensitized Rats

open access: yesJournal of Pharmacological Sciences, 2009
Kujin, the dried root of Sophorae flavescensis, has been used in Chinese folklore medicine against allergy. Evaluation of its anti-allergic potential as well as its mechanism of action has rarely been established.
Shrabanti Dev   +9 more
doaj   +1 more source

Histamine suppresses T helper 17 responses mediated by transforming growth factor-β1 in murine chronic allergic contact dermatitis

open access: yesAIMS Allergy and Immunology, 2018
Allergic skin diseases are caused by the introduction of antigen into the skin. Repeated application of antigens prompts the development of atopic dermatitis (AD) and chronic allergic contact dermatitis (CACD).
Masahiro Seike
doaj   +1 more source

A combined in vitro/in silico approach to identifying off-target receptor toxicity [PDF]

open access: yes, 2018
Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in animal ...
Colley, H   +9 more
core   +4 more sources

Recent Advances in Molecular Pharmacology of the Histamine Systems: Immune Regulatory Roles of Histamine Produced by Leukocytes

open access: yesJournal of Pharmacological Sciences, 2006
.: Accumulating evidence has highlighted the importance of histamine in immune responses. The H1 receptor is involved not only in allergic inflammatory reactions but also in augmentation of helper T cell (Th)1 responses, whereas H2 receptor suppresses Th
Tanaka Satoshi, Ichikawa Atsushi
doaj   +1 more source

Virtual fragment screening on GPCRs: A case study on dopamine D3 and histamine H4 receptors [PDF]

open access: yes, 2014
Prospective structure based virtual fragment screening methodologies on two GPCR targets namely the dopamine D3 and the histamine H4 receptors with a library of 12,905 fragments were evaluated.
Horti, Ferenc   +3 more
core   +1 more source

H1 antihistamines in allergic rhinitis: The molecular pathways of interleukin and toll - like receptor systems

open access: yesJournal of Health Sciences, 2016
The complex interaction between inflammatory mediators in allergic rhinitis (AR) is determined by the role of genetic polymorphisms, including interleukin (IL) and toll-like receptor (TLR) genes.
Jonny Karunia Fajar
doaj   +1 more source

Primary sensory neurons expressing histamine H1-receptor mRNA.

open access: yesFolia Pharmacologica Japonica, 2001
Pharmacological studies have suggested that a subgroup of primary sensory neurons is responsive to histamine via the H1 receptor. However, which type of primary sensory neurons express H1 receptor is not known. We addressed this issue using in situ hybridization histochemistry with a cRNA probe for the guinea pig H1 receptor mRNA.
H, Kashiba, E, Senba
openaire   +3 more sources

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