Results 11 to 20 of about 27,660 (289)

β2-Adrenergic Receptor-Mediated Histamine H1 Receptor Down-Regulation: Another Possible Advantage of β2 Agonists in Asthmatic Therapy

Journal of Pharmacological Sciences, 2004
To clarify heterologous regulation of a receptor is important in considering medication. Histamine constricts the airway smooth muscle through the action to the H1 receptor (H1R), which contributes to asthma.
Nozomi Kawakami, Katsuhiro Miyoshi, Shuhei Horio, Hiroyuki Fukui   +3 more
doaj   +3 more sources

Structure of the human histamine H1 receptor gene [PDF]

Biochemical Journal, 1998
Histamine H1 receptor expression has been reported to change in disorders such as allergic rhinitis, autoimmune myocarditis, rheumatoid arthritis and atherosclerosis. Here we report the isolation and characterization of genomic clones containing the 5´ flanking (regulatory) region of the human histamine H1 receptor gene. An intron of approx. 5.8 kb was
Marianne D. De Backer, Inge Loonen, Peter Verhasselt, Jean‐Marc Neefs, Walter Luyten   +4 more
openalex   +4 more sources

Sensitization of the Histamine H1 Receptor by Increased Ligand Affinity [PDF]

Journal of Biological Chemistry, 1998
Histamine regulates a variety of physiological processes including inflammation, gastric acid secretion, and neurotransmission. The cellular response to histamine is subject to dynamic control, and exaggerated histamine reactivity in response to cysteinyl leukotrienes and other stimuli is important in a variety of different pathological conditions. The
S. Margreet Bloemers, Sander Verheule, Maikel P. Peppelenbosch, Martine J. Smit, Leon G.J. Tertoolen, Siegfried de Laat   +5 more
openalex   +6 more sources

Histamine H1 Receptor Contributes to Vestibular Compensation. [PDF]

J Neurosci, 2019
Vestibular compensation is responsible for the spontaneous recovery of postural, locomotor, and oculomotor dysfunctions in patients with peripheral vestibular lesion or posterior circulation stroke. Mechanism investigation of vestibular compensation is of great importance in both facilitating recovery of vestibular function and understanding the ...
Chen ZP, Zhang XY, Peng SY, Yang ZQ, Wang YB, Zhang YX, Chen X, Wang JJ, Zhu JN.   +8 more
europepmc   +5 more sources

Histamine receptors in GtoPdb v.2023.1 [PDF]

, 2023
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80].
Chazot, Paul, Cowart, Marlon, Fukui, Hiroyuki, Ganellin, C. Robin, Gutzmer, Ralf, Haas, Helmut L., Hill, Stephen J., Hills, Rebecca, Leurs, Rob, Levi, Roberto, Liu, Steve, Panula, Pertti, Schunack, Walter, Schwartz, Jean-Charles, Seifert, Roland, Shankley, Nigel P., Stark, Holger, Thurmond, Robin, Timmerman, Henk, Young, J. Michael   +19 more
core   +3 more sources

Histamine receptors in GtoPdb v.2021.3 [PDF]

, 2021
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 173]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Chazot, Paul, Cowart, Marlon, Fukui, Hiroyuki, Ganellin, C. Robin, Gutzmer, Ralf, Haas, Helmut L., Hill, Stephen J., Hills, Rebecca, Leurs, Rob, Levi, Roberto, Liu, Steve, Panula, Pertti, Schunack, Walter, Schwartz, Jean-Charles, Seifert, Roland, Shankley, Nigel P., Stark, Holger, Thurmond, Robin, Timmerman, Henk, Young, J. Michael   +19 more
core   +2 more sources

Kainate receptor modulation by NETO2 [PDF]

Nature, 599(7884), 325-329 (2021), 2023
Glutamate-gated kainate receptors (KARs) are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission on post-synapse, and modulate transmitter release on pre-synapse. In the brain, the trafficking, gating kinetics, and pharmacology of KARs are tightly regulated by Neuropilin and tolloid-like proteins (Netos).
arxiv   +1 more source

Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation. [PDF]

PLoS ONE, 2014
BACKGROUND: Histamine drives pruritus in allergic skin diseases which clinically constitutes a most disruptive symptom. Skin pathology in allergic skin diseases is crucially influenced by different T-helper subsets. However, the contribution of different
Subhashree Mahapatra, Melanie Albrecht, Barbara Behrens, Adan Jirmo, Georg Behrens, Christina Hartwig, Detlef Neumann, Ulrike Raap, Heike Bähre, Christina Herrick, Anna-Maria Dittrich   +10 more
doaj   +1 more source

Histamine and H1-histamine receptors faster venous circulation [PDF]

Journal of Cellular and Molecular Medicine, 2011
The study has analysed the action of histamine in the rabbit venous system and evaluated its potential role in contraction during increased venous pressure. We have found that a great variety exists in histamine sensitivity and H(1) -histamine receptor expression in various types of rabbit veins.
Galajda, Zoltán, Balla, József, Szentmiklósi, József András, Bíró, Tamás, Czifra, Gabriella, Dobrosi, Nóra, Cseppentő, Ágnes, Patonay, Lajos, Rőszer, Tamás, Balla, György, Popescu, Laurenciu M., Lekli, István, Tósaki, Árpád   +12 more
openaire   +3 more sources

Denatonium benzoate decreases the effect of histamine in vitro and in rats [PDF]

, 2020
Purpose: To evaluate the effect of denatonium benzoate (DB) in histamine-induced model of inflammation and the effect of the selective H1 receptor agonist (2-(2-Pyridyl) ethylamine) on rat gastric smooth muscle strips pretreated with DB.Methods: The anti-
Apostolova, Elisaveta G., Draganova-Filipova, Milena N., Kokova, Vesela Yu, Zagorchev, Plamen I.   +3 more
core   +2 more sources