Results 41 to 50 of about 27,660 (289)

Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy

Life
Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders.
Erwen Kou, Xiaobei Zhang, Baiping Dong, Bo Wang, Yuanjie Zhu   +4 more
doaj   +1 more source

Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor

Frontiers in Immunology, 2022
BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.
Shangze Gao, Shangze Gao, Shangze Gao, Keyue Liu, Wenhan Ku, Dengli Wang, Hidenori Wake, Handong Qiao, Kiyoshi Teshigawara, Masahiro Nishibori   +9 more
doaj   +1 more source

Method for identification of condition-associated public antigen receptor sequences [PDF]

eLife 2018;7:e33050, 2017
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv   +1 more source

Antihistamines in pediatric allergy [PDF]

, 2014
Histamine is a key mediator in allergic diseases, where it exerts most of its effects through the H1 receptor and to a less extent the H2 receptor. H1-antihistamines provide rapid relief of many of the allergic symptoms and are considered the main stay ...
El-Ghoneimy, Dalia H
core   +2 more sources

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, EarlyView.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv   +1 more source

Effects of Olopatadine Hydrochloride, a Histamine H1 Receptor Antagonist, on Histamine-Induced Skin Responses [PDF]

, 2010
Effects of olopatadine hydrochloride, a histamine H1 receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate.
Dainichi, Teruki, Hamada, Takahiro, Hashimoto, Takashi, Ishii, Norito, Karashima, Tadashi, Nakama, Takekuni, Yasumoto, Shinichiro   +6 more
core   +3 more sources

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

ChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia, Anna Maria Schito, Susanna Penco, Chiara Brullo, Marcus Baumann   +4 more
wiley   +1 more source

Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein

Mediators of Inflammation, 2006
Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H1 receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts ...
Kazuya Kishimoto, Satoshi Kaneko, Kenji Ohmori, Tadafumi Tamura, Kazuhide Hasegawa   +4 more
doaj   +1 more source

Role and immunomodulatory profile of histamine receptors by H1 and H2 antagonists [PDF]

, 2008
The present study was designed to delineate the immunomodulatory role of histamine receptors (H1- and H2-) on induction of antibody response to sheep red blood cells (SRBC), as well as the antibody generation profile, in rabbit system, systemically.
Mashiatullah Siddiqui, Mohd. Shahid, Rahat Khan, Trivendra Tripathi   +3 more
core   +1 more source