Results 51 to 60 of about 26,595 (267)

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi, Valtteri Kaasinen, Rimona S. Weil, Juho Joutsa   +3 more
wiley   +1 more source

Identification of Amino Acid Residues Responsible for Agonist-Induced Down-Regulation of Histamine H1 Receptors

Journal of Pharmacological Sciences, 2004
The histamine H1 receptor (H1R) level is dynamically regulated in vivo under various physiological and pathological conditions. The H1R regulation may consist of various processes, and this study focused on the process of receptor trafficking, that is ...
Shuhei Horio, Maki Ogawa, Nozomi Kawakami, Katsumi Fujimoto, Hiroyuki Fukui   +4 more
doaj   +1 more source

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources

The H1 histamine receptor regulates allergic lung responses [PDF]

Journal of Clinical Investigation, 2006
Histamine, signaling via the type 1 receptor (H1R), has been shown to suppress Th2 cytokine production by in vitro cultured T cells. We examined the role of H1R in allergic inflammation in vivo using a murine asthma model. Allergen-stimulated splenic T cells from sensitized H1R-/- mice exhibited enhanced Th2 cytokine production.
Paul J, Bryce, Clinton B, Mathias, Krista L, Harrison, Takeshi, Watanabe, Raif S, Geha, Hans C, Oettgen   +5 more
openaire   +2 more sources

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

Medicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara, Gómez‐Santacana Xavier, Llebaria Amadeu, Rovira Xavier   +3 more
wiley   +1 more source

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms [PDF]

, 2009
The mechanisms that generate itch are poorly understood at both the molecular and cellular levels despite its clinical importance. To explore the peripheral neuronal mechanisms underlying itch, we assessed the behavioral responses (scratching) produced ...
A. I. Basbaum, Andrew, Cao, Caterina, Costa, D. J. Anderson, Davidson, Endoh, G. H. Park, H. Lee, Ikoma, Johanek, Johanek, Katanosaka, LaMotte, Lee, M. I. Simon, Mackenzie, N. Imamachi, Nicholson, Paus, Reddy, S.-K. Han, Schepers, Schmelz, Shim, Simone, Sommer, Sun, Twycross, Uemura, Woo, Zeitz   +32 more
core   +2 more sources

Structure of the human histamine H1 receptor gene [PDF]

Biochemical Journal, 1998
Histamine H1 receptor expression has been reported to change in disorders such as allergic rhinitis, autoimmune myocarditis, rheumatoid arthritis and atherosclerosis. Here we report the isolation and characterization of genomic clones containing the 5´ flanking (regulatory) region of the human histamine H1 receptor gene. An intron of approx. 5.8 kb was
M D, De Backer, I, Loonen, P, Verhasselt, J M, Neefs, W H, Luyten   +4 more
openaire   +2 more sources

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein

Mediators of Inflammation, 2006
Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H1 receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts ...
Kazuya Kishimoto, Satoshi Kaneko, Kenji Ohmori, Tadafumi Tamura, Kazuhide Hasegawa   +4 more
doaj   +1 more source

The role of atrial natriuretic peptide to attenuate inflammation in a mouse skin wound and individually perfused rat mesenteric microvessels. [PDF]

, 2016
We tested the hypothesis that the anti-inflammatory actions of atrial natriuretic peptide (ANP) result from the modulation of leukocyte adhesion to inflamed endothelium and not solely ANP ligation of endothelial receptors to stabilize endothelial barrier
Adamson, Roger H, Clark, Joyce F, Curry, Fitz-Roy E, Jiang, Yanyan, Kim, Min-Ho, Simon, Scott I   +5 more
core   +2 more sources