Results 61 to 70 of about 26,595 (267)

Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey [PDF]

, 2020
Background. The purpose of this study was to gather information on the current assessment and management of patients with moderate-to-severe AD in routine daily practice. Methods.
Armario Hita, José Carlos, Baldrich, Esther Serra, Herráez, L., Jáuregui, Ignacio, Martín-Santiago, Ana, Ortiz de Frutos, Javier, Sastre, Joaquin, Silvestre, Juan Francisco, Universitat Autònoma de Barcelona, Valero, Antonio   +9 more
core   +3 more sources

Basophil Activation Test as Biomarker of Severity and Threshold of Allergic Reactions to Cow's Milk During Oral Food Challenges

Allergy, EarlyView.
The threshold of reactivity during fresh milk challenges was 70% lower than that of baked milk challenges, reflecting the higher allergenicity of fresh milk. BAT was the only biomarker statistically significantly different between severity and threshold groups, for baked milk and fresh milk allergies, respectively.
Holly Boyd, Irene Bartha, Ru‐Xin Foong, Marta Krawiec, Andreina Marques‐Mejias, Hannah F. Marshall, Suzana Radulovic, Faye Harrison, Grammatiki Antoneria, Zainab Jama, Matthew Kwok, Ewa Pietraszewicz, Malak Eghleilib, Cristian Ricci, Tom Marrs, Gideon Lack, George Du Toit, Alexandra F. Santos   +17 more
wiley   +1 more source

Antihistaminic, Anti-Inflammatory, and Antiallergic Properties of the Nonsedating Second-Generation Antihistamine Desloratadine: a Review of the Evidence

World Allergy Organization Journal, 2011
The allergy cascade presents widespread inflammatory and proinflammatory activation, robust cytokine and chemokine signaling, and heterogeneous immune and endothelial responses that lead ultimately to the manifestations of allergic reaction. Histamine, a
G. Walter Canonica, MD, Michael Blaiss, MD   +1 more
doaj   +1 more source

Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation [PDF]

, 2019
Histamine [2-(4-Imidazolyl)-ethylamine] modulates different biological processes, through histamine H1 and H2 receptors, and their respective blockers are widely used in treating allergic and gastric acid-related disorders.
Burghi, Valeria, Davio, Carlos Alberto, Díaz, Antonela Susana, Fernandez, Natalia Cristina, Monczor, Federico, Rodriguez Gonzalez, Angela Paola, Sahores, Ana, Shayo, Carina Claudia, Sosa, Máximo Hernán, Zappia, Carlos Daniel   +9 more
core   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy – in vitro study Short communication

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine, non-sedating, rapid and very long acting used in symptoms associated with allergic ...
Natalia Kordulewska, Anna Cieślińska, Ewa Fiedorowicz, Beata Jarmołowska, Elżbieta Kostyra   +4 more
doaj   +1 more source

Pepducins as a potential treatment strategy for asthma and COPD. [PDF]

, 2018
Current therapies to treat asthma and other airway diseases primarily include anti-inflammatory agents and bronchodilators. Anti-inflammatory agents target trafficking and resident immunocytes and structural cells, while bronchodilators act to prevent or
Benovic, Jeffrey L., Liggett, Stephen B B., Panettieri, Reynold A., Penn, Raymond B., Pera, Tonio   +4 more
core   +2 more sources

Characterization of Human Group 9 Innate Lymphoid Cells in Response to Allergen Immunotherapy in Patients With Allergic Rhinitis

Allergy, EarlyView.
We aimed to report the existence and profile of group 9 innate lymphoid cells (ILC9s). Overall, ILC9 proportions in AR patients show differences compared to healthy subjects and responder SCIT patients. IL‐9 expression decreases after siRNA inhibition of Bach2 suggesting Bach2 could display as a transcription factor of ILC9.
Ya‐Qi Peng, Te Zhang, Xiao‐Qing Liu, Ismail Ogulur, Qi Sun, Beate Ruckert, Bi‐Xin He, De‐Hua Chen, Hideaki Morita, Hui‐Jing Ye, Qing‐Ling Fu, Cezmi A. Akdis   +11 more
wiley   +1 more source

Combination of Leukotoriene Receptor Antagonist With Antihistamine Has an Additive Suppressive Effect on the Up-regulation of H1-Receptor mRNA in the Nasal Mucosa of Toluene 2,4-Diisocyanate-Sensitized Rat

Journal of Pharmacological Sciences, 2013
.: An attempt was made to clarify the additive suppressive effects of pranlukast, a cysteinyl leukotriene–receptor (LTR) antagonist, in combination with chlorpheniramine, an antihistamine, on the up-regulation of histamine H1–receptor (H1R) mRNA in ...
Wakana Kuroda, Yoshiaki Kitamura, Hiroyuki Mizuguchi, Yuko Miyamoto, Bukasa Kalubi, Hiroyuki Fukui, Noriaki Takeda   +6 more
doaj   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source