Results 71 to 80 of about 26,595 (267)

Allergic Rhinoconjunctivitis: the Role of Histamine

Mediators of Inflammation, 1994
Allergic rhinoconjunctivitis is the most common atopic condition encountered in clinical practice. Analysis of the pathogenesis of this condition permits identification of optimal therapeutic targets.
M. Andersson, L. Greiff, C. Svensson
doaj   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

β2-Adrenergic Receptor-Mediated Histamine H1 Receptor Down-Regulation: Another Possible Advantage of β2 Agonists in Asthmatic Therapy

Journal of Pharmacological Sciences, 2004
To clarify heterologous regulation of a receptor is important in considering medication. Histamine constricts the airway smooth muscle through the action to the H1 receptor (H1R), which contributes to asthma.
Nozomi Kawakami, Katsuhiro Miyoshi, Shuhei Horio, Hiroyuki Fukui   +3 more
doaj   +1 more source

Modulation of ConA-induced inflammatory ascites by histamine — Short communication [PDF]

, 2015
The early phase of the ConA-induced inflammatory ascites was studied, with special reference to histamine. Concanavalin A (ConA), a cell-surface binding lectin was injected i.p. (25 mg/kg bw) to mice.
Bach M.K., Baintner K., Baintner K., Feng D., Flessner M.F., Flessner M.F., Hook W.A., Károly Baintner, Roth J., Sullivan T.J., Takata K., Theoharides T.C., Wu N.Z.   +12 more
core   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

In vitro H1-receptor antagonist activity of methanolic extract of tuber of Stephania glabra

Bangladesh Journal of Pharmacology, 2011
In the present study, methanolic extract of tuber of Stephania glabra was evaluated for H1-bloker activity by employing in vitro screening models of guinea pig ileum and goat tracheal chain preparation.
Nisar Ahmad Khan, Dinesh Kumar, Zulfiqar Ali Bhat, Vijender Kumar, Navneet Nagpal, Santosh S. Bhujbal   +5 more
doaj   +1 more source

First description of a histamine receptor of class 2 (HRH2) in a protochordate: expression during blastogenesis and role in regulation of ciliary beat frequency [PDF]

, 2016
Histaminergic receptors belong to the family of seven-transmembrane \u3b1-helix domain receptors classified in mammals into four distinct classes. Despite being widely studied in vertebrates, few data are available on the invertebrate receptors, with ...
Cima, Francesca
core  

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cross-Desensitization and Cointernalization of H1 and H2 Histamine Receptors Reveal New Insights into Histamine Signal Integration [PDF]

, 2013
G-protein coupled receptor (GPCR) signaling does not result from sequential activation of a linear pathway of proteins/enzymes, but rather from complex interactions of multiple, branched signaling routes, ie, signaling networks.
Alonso, Maria Natalia, Baldi, Alberto, Davio, Carlos Alberto, Fernández, Natalia Brenda, Gutkind, J. Silvio, Monczor, Federico, Notcovich, Cintia Karina, Shayo, Carina Claudia, Simaan, May   +8 more
core   +2 more sources

Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells. [PDF]

PLoS ONE, 2012
The hypothalamus in the brain is the main center for appetite control and integrates signals from adipose tissue and the gastrointestinal tract. Antidepressants are known to modulate the activities of hypothalamic neurons and affect food intake, but the ...
Ji-Ah Kang, Keimin Lee, Kwang Min Lee, Sukhee Cho, Jinsoo Seo, Eun-Mi Hur, Chul-Seung Park, Ja-Hyun Baik, Se-Young Choi   +8 more
doaj   +1 more source