Results 131 to 140 of about 8,363 (180)

Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists

Drug Safety, 2001
The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions. Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction.
A A, Fisher, D G, Le Couteur
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Conformational analyses on histamine H2-receptor antagonists

Journal of Computer-Aided Molecular Design, 1990
In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations. The drugs studied were cimetidine, ranitidine, famotidine, roxatidine and the conformationally more restricted ICI127032.
Hans-Dieter Höltje, Anita Batzenschlager   +1 more
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Metiamide—An orally active histamine H2-receptor antagonist

Agents and Actions, 1973
Metiamide has been found to be about 10 times more active than burimamide in vitro in antagonizing histamine H2-receptors and nearly 5 times more active in vivo as an antagonist of histamine or pentagastrin-stimulated secretion. Effective oral ED50 doses for inhibition have been estimated as 25 μmole kg−1 against basal secretion in rats and 16 μmole kg−
J W, Black, W A, Duncan, J C, Emmett, C R, Ganellin, T, Hesselbo, M E, Parsons, J H, Wyllie   +6 more
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Histamine H2-receptor antagonists.

Advances in internal medicine, 1978
Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to all known secretagogues and, in contrast to anticholinergic drugs ...
M, Feldman, C T, Richardson
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Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa

The Histochemical Journal, 1977
Histamine stimulates acid secretion by the parietal cell and this secretion is inhibited by the histamine H2-receptor antagonists. Whole body autoradiography showed that radioactivity from 14C-histamine was localized in the artery walls of the stomach and in the muscularis mucosae, but that the level in the fundic mucosa was the same as the blood. When
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Structural Requirements for Histamine H2 Agonists and H2 Antagonists

1991
This chapter reviews the structural requirements for H2 agonists and antagonists. Section B discusses the agonists, which are divided into three classes: the non-selective histamine analogues, showing H2 activity as well as H1 and H3 activity; dimaprit, a selective, but moderately active agonist which allows no substitution without a dramatic fall in ...
H. van der Goot, A. Bast, H. Timmerman
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HISTAMINE H2 ANTAGONISTS AND THE HEART

The Lancet, 1982
David Jack, R.N. Smith, D.A. Richards, R.R. Shah   +3 more
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The pharmacology of histamine H2-receptor antagonists.

Methods and findings in experimental and clinical pharmacology, 1989
The structure of the first histamine H2-receptor antagonist, burimamide was described in 1972. Since then, numerous compounds with diverse chemical structures have been shown to possess H2-receptor antagonist activity. Most of these compounds comprise an aromatic ring and polar group linked by a flexible chemical chain.
J G, Mills, J R, Wood
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Histamine and histamine H1- and H2-receptor antagonists in acute inflammation

Biochemical Society Transactions, 1980
D A, Owen, D F, Woodward
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Histamine H2 Receptor-Antagonists

JAMA: The Journal of the American Medical Association, 1976
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