Results 171 to 180 of about 356,503 (221)
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Histamine H2-Receptor Antagonists
Nursing Clinics of North America, 1991In summary, histamine initiates acid secretion by stimulating the H2 subtype histamine receptor on parietal cells. Cimetidine, rantidine, famotidine, and nizantidine are histamine H2-receptor antagonists that block this action of histamine, reducing gastric acid output and concentration under both basal and stimulated conditions.
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Nephrotoxicity and Hepatotoxicity of Histamine H2 Receptor Antagonists
Drug Safety, 2001The extensive use of selective histamine H2 receptor antagonists provides a unique opportunity to describe very rare adverse drug reactions. Although mild elevation of serum creatinine level following the administration of cimetidine is relatively common, acute interstitial nephritis (AIN) is a rare hypersensitivity reaction.
A A, Fisher, D G, Le Couteur
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Conformational analyses on histamine H2-receptor antagonists
Journal of Computer-Aided Molecular Design, 1990In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations. The drugs studied were cimetidine, ranitidine, famotidine, roxatidine and the conformationally more restricted ICI127032.
Hans-Dieter Höltje +1 more
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Prolactin responses to histamine H2 receptor antagonists
Acta Endocrinologica, 1980Abstract. We have compared the effects of cimetidine and SK&F 92994, a new more potent histamine H2 receptor antagonist, on serum prolactin, and also assessed the effect of the H2 receptor agonist impromidine on the response to cimetidine. As previously reported, cimetidine 200 mg given as an iv bolus dose produced a marked rise in serum prolactin,
P C, Sharpe +4 more
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Histamine H2-Antagonists-Past, Present and Future
Journal of Clinical Gastroenterology, 1983In this selective review of histamine H2-antagonists, we emphasize the significance of burimamide, the first specific H2-antagonist, in physiology and pharmacology and describe how its discovery led to the development of cimetidine as a new treatment of acid-aggravated disease of the alimentary tract.
R T, Brittain, D, Jack
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Metiamide—An orally active histamine H2-receptor antagonist
Agents and Actions, 1973Metiamide has been found to be about 10 times more active than burimamide in vitro in antagonizing histamine H2-receptors and nearly 5 times more active in vivo as an antagonist of histamine or pentagastrin-stimulated secretion. Effective oral ED50 doses for inhibition have been estimated as 25 μmole kg−1 against basal secretion in rats and 16 μmole kg−
J W, Black +6 more
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Localization of histamine and histamine H2-receptor antagonists in the gastric mucosa
The Histochemical Journal, 1977Histamine stimulates acid secretion by the parietal cell and this secretion is inhibited by the histamine H2-receptor antagonists. Whole body autoradiography showed that radioactivity from 14C-histamine was localized in the artery walls of the stomach and in the muscularis mucosae, but that the level in the fundic mucosa was the same as the blood. When
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Histamine H2-receptor antagonists.
Advances in internal medicine, 1978Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to all known secretagogues and, in contrast to anticholinergic drugs ...
M, Feldman, C T, Richardson
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Structural Requirements for Histamine H2 Agonists and H2 Antagonists
1991This chapter reviews the structural requirements for H2 agonists and antagonists. Section B discusses the agonists, which are divided into three classes: the non-selective histamine analogues, showing H2 activity as well as H1 and H3 activity; dimaprit, a selective, but moderately active agonist which allows no substitution without a dramatic fall in ...
H. van der Goot, A. Bast, H. Timmerman
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