Results 1 to 10 of about 6,313 (204)

The Impact of H1–H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis [PDF]

Pharmaceuticals
Background/Objectives: The global prevalence and incidence of inflammatory bowel diseases have risen in the past two decades. Among them, Crohn’s disease and ulcerative colitis are still challenging to treat due to vascular and proliferative alterations.
Bartosz Bogielski, Katarzyna Michalczyk, Wojciech Gębski, Katarzyna Rozpędek, Elżbieta Szulińska, Bartosz Tempka, Aleksandra Zorychta, Elżbieta Chełmecka, Ewa Kaczmar, Piotr Głodek, Jakub John, Kamil Nikiel, Bronisława Skrzep-Poloczek, Jerzy Jochem, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Dominika Stygar   +16 more
doaj   +2 more sources

Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice [PDF]

Molecular Brain
The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 receptor inverse
Sentaro Kaita, Yoshikazu Morishita, Kenta Kobayashi, Hiroshi Nomura   +3 more
doaj   +2 more sources

Computational approaches for the identification of potential HDAC2 inhibitors and histamine H3 receptor antagonists from Berberis vulgaris: a dual mechanistic approach for autism spectrum disorder treatment [PDF]

Open Life Sciences
Autism spectrum disorder (ASD) encompasses early emerging deficits in repetitive sensory-motor behaviors and social communication. Rooted in a solid genetic foundation, ASD exhibits diversity among individuals but consistently manifests core features in ...
Sarwar Tarique, Obaid A Alharbi Hajed, Alhumaydhi Fahad A, Khan Rashid Mumtaz, Rahmani Arshad Husain   +4 more
doaj   +2 more sources

Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta‐Analysis [PDF]

Neuropsychopharmacology Reports
Aim Whether histamine H3 receptor antagonists (H3R‐ANTs)/inverse agonists (H3R‐IAs) provides benefit for the treatment of schizophrenia remains unclear. This meta‐analysis was conducted to address the above clinical question.
Yasufumi Nishii, Kenji Sakuma, Shun Hamanaka, Nakao Iwata, Taro Kishi   +4 more
doaj   +2 more sources

Simultaneous inhibition of cholinesterase and antagonism of histamine H3 receptors alleviates cognitive deficits and mitigates apoptosis in scopolamine-induced amnesia in mice [PDF]

Frontiers in Behavioral Neuroscience
IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory deficits. Mounting evidence highlights the role of cholinergic and histaminergic neurotransmissions in the pathophysiology of ...
Wajd Ebdah, Wajd Ebdah, Shilu Deepa Thomas, Shilu Deepa Thomas, Nermin Eissa, Petrilla Jayaprakash, Petrilla Jayaprakash, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek, Bassem Sadek   +10 more
doaj   +2 more sources

Histamine receptors in GtoPdb v.2021.3 [PDF]

, 2021
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 173]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and rat
Chazot, Paul, Cowart, Marlon, Fukui, Hiroyuki, Ganellin, C. Robin, Gutzmer, Ralf, Haas, Helmut L., Hill, Stephen J., Hills, Rebecca, Leurs, Rob, Levi, Roberto, Liu, Steve, Panula, Pertti, Schunack, Walter, Schwartz, Jean-Charles, Seifert, Roland, Shankley, Nigel P., Stark, Holger, Thurmond, Robin, Timmerman, Henk, Young, J. Michael   +19 more
core   +2 more sources

Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]

, 2013
The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto, Fernández, Natalia Brenda, Fitzsimons, Carlos, Monczor, Federico, Shayo, Carina Claudia   +4 more
core   +13 more sources

Histamine receptors in GtoPdb v.2023.1 [PDF]

, 2023
Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80].
Chazot, Paul, Cowart, Marlon, Fukui, Hiroyuki, Ganellin, C. Robin, Gutzmer, Ralf, Haas, Helmut L., Hill, Stephen J., Hills, Rebecca, Leurs, Rob, Levi, Roberto, Liu, Steve, Panula, Pertti, Schunack, Walter, Schwartz, Jean-Charles, Seifert, Roland, Shankley, Nigel P., Stark, Holger, Thurmond, Robin, Timmerman, Henk, Young, J. Michael   +19 more
core   +3 more sources

QSAR and Molecular Docking Studies on Non-Imidazole-Based Histamine H3 Receptor Antagonists [PDF]

Pharmaceutical Sciences, 2020
Background: In the recent years, histamine H3 receptor (H3R) has been receiving increasing attention in pharmacotherapy of neurological disorders.
Maryam Hamzeh-Mivehroud, Zoha Khoshravan-Azar, Siavoush Dastmalchi   +2 more
doaj   +1 more source

Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells

Scientific Reports, 2021
Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is ...
Nobuki Matsumoto, Miku Ebihara, Shiori Oishi, Yuku Fujimoto, Tomoko Okada, Toru Imamura   +5 more
doaj   +1 more source