Results 101 to 110 of about 6,313 (204)

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation [PDF]

, 2010
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molecules will alter complex behaviors. We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior ...
Arvanites, Anthony, Haggarty, Stephen J., Jang, Sumin, Kokel, David, Lam, Kelvin, Peterson, Randall T., Prober, David A., Rihel, Jason, Rubin, Lee L., Schier, Alexander F., Zimmerman, Steven   +10 more
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Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats

Drug Design, Development and Therapy, 2016
Bassem Sadek,1 Ali Saad,1 Gniewomir Latacz,2 Kamil Kuder,2 Agnieszka Olejarz,2 Tadeusz Karcz,2 Holger Stark,3 Katarzyna Kieć-Kononowicz2 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates ...
Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kiec´-Kononowicz K   +7 more
doaj  

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats

Frontiers in Neuroscience, 2018
The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted.
Nermin Eissa, Nadia Khan, Shreesh K. Ojha, Dorota Łazewska, Katarzyna Kieć-Kononowicz, Bassem Sadek   +5 more
doaj   +1 more source

Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues [PDF]

, 2020
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
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Functional Selectivity of Allosteric Interactions within GPCR oligomers: the Dopamine D1-D3 Receptor Heterotetramer [PDF]

, 2014
The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies suggested that this heteromer could be involved in the ability of D3R agonists to potentiate ...
Antoni Cortés, Carme Lluís, Enric I. Canela, Estefania Moreno, Gemma Navarro, Hideaki Yano, Josefa Mallol, Lee, Marta Sánchez-Soto, Ning-Sheng Cai, Peter J. McCormick, Sandeep Kumar-Barodia, Sergi Ferré, Staley, Vicent Casadó, Xavier Guitart, Yamini T. Naidu   +16 more
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Non-Imidazole Histamine H3 Ligands. Part VII. Synthesis, In Vitro and In Vivo Characterization of 5-Substituted-2-thiazol-4-n-propylpiperazines

Molecules, 2018
H3 receptors present on histaminergic and non-histaminergic neurons, act as autoreceptors or heteroreceptors controlling neurotransmitter release and synthesis.
Roman Guryn, Marek Staszewski, Anna Stasiak, Daniel McNaught Flores, Wiesława Agnieszka Fogel, Rob Leurs, Krzysztof Walczyński   +6 more
doaj   +1 more source

Chemogenetic activation of histamine neurons promotes retrieval of apparently lost memories

Molecular Brain
Memory retrieval can become difficult over time, but it is important to note that memories that appear to be forgotten might still be stored in the brain, as shown by their occasional spontaneous retrieval.
Yuto Yokoi, Ayame Kubo, Kyoka Nishimura, Yuki Takamura, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura   +6 more
doaj   +1 more source

Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications

Drugs and Drug Candidates
Current treatment options for Alzheimer’s disease target neurotransmitters following the disease onset, and they offer limited efficacy without slowing down the disease progression.
Nagaraju Bandaru, Sarad Pawar Naik Bukke, Veera Mani Deepika Pedapati, Gurugubelli Sowjanaya, Vangmai Swaroopa Suggu, Swathi Nalla, Prashik Bhimrao Dudhe, Joseph Obiezu Chukwujekwu Ezeonwumelu, Abdullateef Isiaka Alagbonsi, Hope Onohuean   +9 more
doaj   +1 more source

Alleviation of Autophagic Deficits and Neuroinflammation by Histamine H3 Receptor Antagonist E159 Ameliorates Autism-Related Behaviors in BTBR Mice

Pharmaceuticals
Background/Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by social interaction difficulties, repetitive behaviors, and immune dysregulation with elevated pro-inflammatory markers.
Shilu Deepa Thomas, Petrilla Jayaprakash, Nurfirzana Z. H. J. Marwan, Ezzatul A. B. A. Aziz, Kamil Kuder, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek   +7 more
doaj   +1 more source

Histaminosis alimentaria no alérgica (HANA) [PDF]

, 2016
En los últimos años se ha observado un creciente interés por las patologías relacionadas con la alimentación, ya sean procesos alérgicos, intolerancias alimentarias, sensibilidad o histaminosis.
Planas Prieto, Inés
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