Results 21 to 30 of about 3,102 (198)
QSAR and Molecular Docking Studies on Non-Imidazole-Based Histamine H3 Receptor Antagonists [PDF]
Pharmaceutical Sciences, 2020 Background: In the recent years, histamine H3 receptor (H3R) has been receiving increasing attention in pharmacotherapy of neurological disorders.
Maryam Hamzeh-Mivehroud +2 more
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Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells
Scientific Reports, 2021 Cancer therapy is often hampered by the disease’s development of resistance to anticancer drugs. We previously showed that the autonomously upregulated product of fibroblast growth factor 13 gene (FGF13; also known as FGF homologous factor 2 (FHF2)) is ...
Nobuki Matsumoto +5 more
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Amine-constrained pyridazinone histamine H3 receptor antagonists
Bioorganic & Medicinal Chemistry Letters, 2011 Babu G. Sundar +7 more
openalex +2 more sources
QSAR study on the histamine (H3) receptor antagonists using the genetic algorithm: Multi parameter linear regression [PDF]
Journal of the Serbian Chemical Society, 2012 A quantitative structure activity relationship (QSAR) model has been produced for predicting antagonist potency of biphenyl derivatives as human histamine (H3) receptors. The molecular structures of the compounds are numerically represented by various
Adimi Maryam +2 more
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Role of Substance P on Histamine H3 Antagonist-Induced Scratching Behavior in Mice
Journal of Pharmacological Sciences, 2006 .: The purpose of the present study was to investigate the involvement of chemical mediators, other than histamine, in the scratching behavior induced by H3 antagonists.
Maria Alejandra Hossen +5 more
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Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors
BMC Neuroscience, 2009 Background Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. The site of action of these drugs however has not been elucidated yet.
Zucca Gianpiero +5 more
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Histamine and Delirium: Current Opinion
Frontiers in Pharmacology, 2019 Delirium is a very common, but refractory clinical state, notably present in intensive care and in the growing aging community. It is characterized by fluctuating disturbances in a number of key behavioral features, namely cognition, mood, attention ...
Paul L. Chazot +3 more
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Histamine H3 Receptor Antagonists Go to Clinics
Biological and Pharmaceutical Bulletin, 2008 Within the recent years novel lead optimisations for histamine H(3) receptor antagonists made their way from bench to bedside. Structure-activity relationships, cross-affinities and side effects as well as pharmacokinetic profiling will be discussed on selected promising compound series.
Kerstin, Sander +2 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2008 The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the role ...
Feiyong Jia +9 more
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Histamine and migraine revisited: mechanisms and possible drug targets
The Journal of Headache and Pain, 2019 Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm +2 more
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