Results 31 to 40 of about 3,102 (198)

Identification of histamine H3 receptor antagonists

The FASEB Journal, 2007
Histamine H 3 receptors (H 3 R) regulate the release of histamine and other neurotransmitters in the brain. H 3 R have been shown to modulate many functions, including feeding, sleep, and cognition, making them ...
Andria Lee Del Tredici, Jorgen Eskildsen, Carsten B Andersen, Jian‐Nong Ma, Steven Ohrmund, Lauren Petersen, Pey‐Lih Littler, Derek Nugyen, Luke Fairbairn, Jelveh Lameh, Erika A Currier, Hans H Schiffer, Ethan Burstein, Roger Olsson, Fabrice Piu   +14 more
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HISTAMINE H3 RECEPTOR INVERSE AGONISTS ON COGNITIVE AND MOTOR PROCESSES: RELEVANCE TO ALZHEIMER’S DISEASE, ADHD, SCHIZOPHRENIA AND DRUG ABUSE

Frontiers in Systems Neuroscience, 2012
Histamine H3 receptor antagonists/ inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric ...
Divya eVohora, Malay eBhowmik
doaj   +1 more source

Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor

Frontiers in Immunology, 2022
BackgroundSystemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output.
Shangze Gao, Shangze Gao, Shangze Gao, Keyue Liu, Wenhan Ku, Dengli Wang, Hidenori Wake, Handong Qiao, Kiyoshi Teshigawara, Masahiro Nishibori   +9 more
doaj   +1 more source

The impact of pitolisant, an H3 receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels

Scientific Reports, 2022
Histamine is a neurotransmitter that modulates neuronal activity and regulates various brain functions. Histamine H3 receptor (H3R) antagonists/inverse agonists enhance its release in most brain regions, including the cerebral cortex, which improves ...
Kyosuke Hirano, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura   +3 more
doaj   +1 more source

Recent Advances in Molecular Pharmacology of the Histamine Systems: Physiology and Pharmacology of Histamine H3 Receptor: Roles in Feeding Regulation and Therapeutic Potential for Metabolic Disorders

Journal of Pharmacological Sciences, 2006
.: Histamine H3 receptors (H3Rs) are autoreceptors that negatively regulate the release of histamine and other neurotransmitters such as norepinephrine, dopamine, and acetylcholine in the central nervous system (CNS).
Tokita Shigeru, Takahashi Kazuhiko, Kotani Hidehito   +2 more
doaj   +1 more source

Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?

Frontiers in Pharmacology, 2020
Many behavioral and psychological symptoms of dementia (BPSD) share similarities in executive functioning and communication deficits with those described in several neuropsychiatric disorders, including Alzheimer’s disease (AD), epilepsy, schizophrenia ...
Nermin Eissa, Nermin Eissa, Adel Sadeq, Astrid Sasse, Bassem Sadek, Bassem Sadek   +5 more
doaj   +1 more source

Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury

Stem Cell Reports, 2019
Summary: The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to ...
Rujia Liao, Youchao Chen, Li Cheng, Lishi Fan, Han Chen, Yushan Wan, Yi You, Yanrong Zheng, Lei Jiang, Zhong Chen, Xiangnan Zhang, Weiwei Hu   +11 more
doaj   +1 more source

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Frontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada   +7 more
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Therapeutic potential of histamine H3 receptor agonists and antagonists

Trends in Pharmacological Sciences, 1998
The histamine H3 receptor was discovered 15 years ago, and many potent and selective H3 receptor agonists and antagonists have since been developed. Currently, much attention is being focused on the therapeutic potential of H3 receptor ligands. In this review, Rob Leurs, Patrizio Blandina, Clark Tedford and Henk Timmerman describe the available H3 ...
R. LEURS, BLANDINA, PATRIZIO, C. TEDFORD, H. TIMMERMAN   +3 more
openaire   +5 more sources

Histamine H3 Heteroreceptors Suppress Glutamatergic and GABAergic Synaptic Transmission in the Rat Insular Cortex

Frontiers in Neural Circuits, 2017
Histamine H3 receptors are autoreceptors that regulate histamine release from histaminergic neuronal terminals. The cerebral cortex, including the insular cortex (IC), expresses abundant H3 receptors; however, the functions and mechanisms of H3 receptors
Hiroki Takei, Hiroki Takei, Kiyofumi Yamamoto, Kiyofumi Yamamoto, Yong-Chul Bae, Tetsuo Shirakawa, Masayuki Kobayashi, Masayuki Kobayashi, Masayuki Kobayashi   +8 more
doaj   +1 more source