Results 41 to 50 of about 6,313 (204)

Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?

Frontiers in Pharmacology, 2020
Many behavioral and psychological symptoms of dementia (BPSD) share similarities in executive functioning and communication deficits with those described in several neuropsychiatric disorders, including Alzheimer’s disease (AD), epilepsy, schizophrenia ...
Nermin Eissa, Nermin Eissa, Adel Sadeq, Astrid Sasse, Bassem Sadek, Bassem Sadek   +5 more
doaj   +1 more source

Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury

Stem Cell Reports, 2019
Summary: The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to ...
Rujia Liao, Youchao Chen, Li Cheng, Lishi Fan, Han Chen, Yushan Wan, Yi You, Yanrong Zheng, Lei Jiang, Zhong Chen, Xiangnan Zhang, Weiwei Hu   +11 more
doaj   +1 more source

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Frontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada   +7 more
doaj   +1 more source

Heteroreceptor complexes formed by dopamine D1, histamine H3 and N-methyl-D-aspartate glutamate receptors as targets to prevent neuronal death in Alzheimer's disease [PDF]

, 2017
Alzheimer’s disease (AD) is a neurodegenerative disorder causing progressive memory loss and cognitive dysfunction. Anti-AD strategies targeting cell receptors consider them as isolated units. However, many cell surface receptors cooperate and physically
A Thathiah, AD Medhurst, AI Hersi, Antonio Cortés, C Ferrada, C Fiorentini, C Pillot, Carme Lluís, CG Mcnamara, D Wang, D Wilkinson, David Moreno-Delgado, DO Borroto-Escuela, DR Borchelt, DR Borchelt, E Moreno, E Moreno, Enric I. Canela, Estefanía Moreno, FJS Lee, G Navarro, G Navarro, G Navarro, G Navarro, Gemma Navarro, H Kaphzan, HJ Seong, IM Mazurkiewicz-Kwilecki, J Chen, J Wu, JD Brioni, Josefa Mallol, JY Koh, L Fernández-Novoa, M Wang, Mar Rodríguez-Ruiz, MB Passani, NP Sidharthan, P Giménez-Xavier, P Panula, Peter J. McCormick, PL Chazot, R Cacabelos, RA Grove, Rafael Franco, RF Cowburn, RJ Rodrigues, S Jürgensen, S-M Jeon, Vicent Casadó, WD Le   +50 more
core   +1 more source

Therapeutic potential of histamine H3 receptor agonists and antagonists

Trends in Pharmacological Sciences, 1998
The histamine H3 receptor was discovered 15 years ago, and many potent and selective H3 receptor agonists and antagonists have since been developed. Currently, much attention is being focused on the therapeutic potential of H3 receptor ligands. In this review, Rob Leurs, Patrizio Blandina, Clark Tedford and Henk Timmerman describe the available H3 ...
R. LEURS, BLANDINA, PATRIZIO, C. TEDFORD, H. TIMMERMAN   +3 more
openaire   +5 more sources

Drug design for CNS diseases: polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies [PDF]

, 2016
Support was kindly provided by the EU COST Action CM1103. DA, KN, and JV kindly acknowledge national project number 172033 and OI1612039 supported by the Ministry of the Republic of Serbia.
Agbaba, Danica, Djikic, Teodora, Mavridis, Lazaros, Mitchell, John B. O., Nikolic, Katarina, Vucicevic, Jelica, Yelekçi, Kemal, Yelekçi, Kemal   +7 more
core   +3 more sources

Histamine H3 Heteroreceptors Suppress Glutamatergic and GABAergic Synaptic Transmission in the Rat Insular Cortex

Frontiers in Neural Circuits, 2017
Histamine H3 receptors are autoreceptors that regulate histamine release from histaminergic neuronal terminals. The cerebral cortex, including the insular cortex (IC), expresses abundant H3 receptors; however, the functions and mechanisms of H3 receptors
Hiroki Takei, Hiroki Takei, Kiyofumi Yamamoto, Kiyofumi Yamamoto, Yong-Chul Bae, Tetsuo Shirakawa, Masayuki Kobayashi, Masayuki Kobayashi, Masayuki Kobayashi   +8 more
doaj   +1 more source

Integrative role of the histaminergic system in feeding and taste perception

Frontiers in Systems Neuroscience, 2012
Feeding behavior is regulated by a complex interplay of many endogenous substances, such as peptides and neurotransmitters in the central nervous system.
Tomoko eIshizuka, Atsushi eYamatodani
doaj   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source