Results 71 to 80 of about 3,102 (198)

Letter to the Editor in Response to “Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta‐Analysis” by Nishii et al.

Neuropsychopharmacology Reports, Volume 45, Issue 4, December 2025.
Muhammad Farhan
wiley   +1 more source

Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer’s disease

Translational Psychiatry
Histamine H3 receptor (H3R) antagonists regulate histamine release that modulates neuronal activity and cognitive function. Although H3R is elevated in Alzheimer’s disease (AD) patients, whether H3R antagonists can rescue AD-associated neural impairments
Yang Zou, Linhan Yang, Jiahui Zhu, Jihua Fan, Hanrun Zheng, Xiang Liao, Zhiqi Yang, Kuan Zhang, Hongbo Jia, Arthur Konnerth, Yan-jiang Wang, Chunqing Zhang, Yun Zhang, Sunny C. Li, Xiaowei Chen   +14 more
doaj   +1 more source

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats

Drug Design, Development and Therapy, 2016
Bassem Sadek,1 Ali Saad,1 Gniewomir Latacz,2 Kamil Kuder,2 Agnieszka Olejarz,2 Tadeusz Karcz,2 Holger Stark,3 Katarzyna Kieć-Kononowicz2 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates ...
Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kiec´-Kononowicz K   +7 more
doaj  

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats

Frontiers in Neuroscience, 2018
The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted.
Nermin Eissa, Nadia Khan, Shreesh K. Ojha, Dorota Łazewska, Katarzyna Kieć-Kononowicz, Bassem Sadek   +5 more
doaj   +1 more source

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors [PDF]

, 2020
Dorota Łażewska, Agnieszka Olejarz‐Maciej, David Reiner‐Link, Maria Kaleta, Gniewomir Latacz, Małgorzata Zygmunt, Agata Doroż-Płonka, Tadeusz Karcz, Annika Frank, Holger Stark, Katarzyna Kieć‐Kononowicz   +10 more
openalex   +1 more source

Non-Imidazole Histamine H3 Ligands. Part VII. Synthesis, In Vitro and In Vivo Characterization of 5-Substituted-2-thiazol-4-n-propylpiperazines

Molecules, 2018
H3 receptors present on histaminergic and non-histaminergic neurons, act as autoreceptors or heteroreceptors controlling neurotransmitter release and synthesis.
Roman Guryn, Marek Staszewski, Anna Stasiak, Daniel McNaught Flores, Wiesława Agnieszka Fogel, Rob Leurs, Krzysztof Walczyński   +6 more
doaj   +1 more source

The Potent and Selective Histamine H3 Receptor Antagonist E169 Counteracts Cognitive Deficits and Mitigates Disturbances in the PI3K/AKT/GSK-3β Signaling Pathway in MK801-Induced Amnesia in Mice [PDF]

, 2023
Sabna Abdalla, Nermin Eissa, Petrilla Jayaprakash, Rami Beiram, Kamil Kuder, Dorota Łażewska, Katarzyna Kieć‐Kononowicz, Bassem Sadek   +7 more
openalex   +1 more source

Chemogenetic activation of histamine neurons promotes retrieval of apparently lost memories

Molecular Brain
Memory retrieval can become difficult over time, but it is important to note that memories that appear to be forgotten might still be stored in the brain, as shown by their occasional spontaneous retrieval.
Yuto Yokoi, Ayame Kubo, Kyoka Nishimura, Yuki Takamura, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura   +6 more
doaj   +1 more source

Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications

Drugs and Drug Candidates
Current treatment options for Alzheimer’s disease target neurotransmitters following the disease onset, and they offer limited efficacy without slowing down the disease progression.
Nagaraju Bandaru, Sarad Pawar Naik Bukke, Veera Mani Deepika Pedapati, Gurugubelli Sowjanaya, Vangmai Swaroopa Suggu, Swathi Nalla, Prashik Bhimrao Dudhe, Joseph Obiezu Chukwujekwu Ezeonwumelu, Abdullateef Isiaka Alagbonsi, Hope Onohuean   +9 more
doaj   +1 more source

Benzophenone Derivatives and Related Compounds as Potent Histamine H3-Receptor Antagonists and Potential PET/SPECT Ligands [PDF]

, 2001
Astrid Sasse, Xavier Ligneau, Bassem Sadek, Sigurd Elz, Heinz H. Pertz, C. Robin Ganellin, Jean‐Michel Arrang, Jean‐Charles Schwartz, Walter Schunack, Holger Stark   +9 more
openalex   +1 more source