Results 81 to 90 of about 6,313 (204)
New antihistamines: a critical view [PDF]
, 2006 OBJECTIVE: To perform a critical evaluation of the more recent H1 antihistamines and the various terms used to describe them, based on a review of evidence on their role in the treatment of allergic disorders.
Camelo-nunes, Inês Cristina
core +3 more sources
Frontiers in Pharmacology, 2017 The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established.
Alaa Alachkar +3 more
doaj +1 more source
Chemical Genetic Identification of the Histamine H1 Receptor as a Stimulator of Insulin-Induced Adipogenesis [PDF]
, 2004 A large collection of bioactive compounds with diverse biological effects can be used as probes to elucidate new biological mechanisms that influence a particular cellular process.
Yoshinori Kawazoe +40 more
core +3 more sources
Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu +4 more
wiley +1 more source
Frontiers in Pharmacology, 2017 The histamine receptors (HRs) are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H3R and H4R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson’s, and Alzheimer’s
Michelle F. Corrêa +10 more
doaj +1 more source
Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? [PDF]
, 2015 The spread of "obesity epidemic" and the poor efficacy of many anti-obesity therapies in the long-term highlight the need to develop novel efficacious therapy. This necessity stimulates a large research effort to find novel mechanisms controlling feeding
Gaetani, Silvana +4 more
core +2 more sources
Allergy, Volume 81, Issue 2, Page 513-523, February 2026.IgH repertoire sequencing of a large atopic dermatitis cohort reveal reduced IgE somatic hypermutation and increased IgE diversity associated with food allergen sensitization. Presence of a dog during the first year of life is associated with increased IgE somatic hypermutation, possibly countering the effect of food sensitization.
Kirandeep K. Gill +18 more
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun +16 more
wiley +1 more source
Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]
, 2007 Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan +29 more
core +3 more sources
Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method
Scientific Reports, 2017 Virtual screening offers an efficient alternative to high-throughput screening in the identification of pharmacological tools and lead compounds. Virtual screening is typically based on the matching of target structures or ligand pharmacophores to ...
Ida Osborn Frandsen +7 more
doaj +1 more source