Results 341 to 350 of about 2,435,179 (382)

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, Volume 19, Issue 6, Page 1737-1750, June 2025.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Subtype-specific dysregulation of biogenic amine-related genes and miRNAs in breast cancer: identification of DRD2, HRH2, and HRH4 as potential therapeutic targets in TNBC and HER2+ subtypes. [PDF]

Breast Cancer Res Treat
Sirek A, Sirek T, Nowakowski R, Borawski P, Ossowski P, Mitka-Krysiak K, Zmarzły N, Boroń K, Chalcarz M, Kuraszewska B, Szulik M, Boroń D, Grabarek BO.   +12 more
europepmc   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

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Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice

Science Translational Medicine, 2022
The gut microbiota has been implicated in chronic pain disorders, including irritable bowel syndrome (IBS), yet specific pathophysiological mechanisms remain unclear.
G. De Palma, C. Shimbori, D. Reed, Yang Yu, V. Rabbia, Jun Lu, N. Jimenez-Vargas, J. Sessenwein, C. López-López, M. Pigrau, J. Jaramillo-Polanco, Yong Zhang, Lauren Baerg, Ahmad Manzar, J. Pujo, X. Bai, M. Pinto-Sanchez, A. Caminero, K. Madsen, M. Surette, M. Beyak, A. Lomax, E. Verdú, S. Collins, S. Vanner, P. Bercik   +25 more
semanticscholar   +1 more source

Terfenadine (Seldane) is a potent and selective histamine H1 receptor antagonist in asthmatic airways.

American Review of Respiratory Disease, 2015
Terfenadine (Seldane) is a new, highly potent H1 histamine receptor antagonist that in clinically effective doses is free of side effects. Because the low potency and specificity of many H1 receptor antagonists have made it difficult to define the ...
P. Rafferty, S. Holgate
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Brief report: first identification of H₄ histamine receptor in healthy salivary glands and in focal sialadenitis in Sjögren's syndrome.

Arthritis & Rheumatism, 2012
OBJECTIVE The conventional H(1) and H(2) histamine receptors have >10,000-fold lower avidity for histamine than H(4) histamine receptor, which has been implicated in autoimmune diseases. This study was undertaken to compare H(4) histamine receptor levels
V. Stegaev, T. Sillat, P. Porola, A. Hänninen, A. Falus, D. Mieliauskaitė, E. Buzás, Ž. Rotar, Z. Mackiewicz, H. Stark, P. Chazot, Y. Konttinen   +11 more
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Histamine and histamine receptor antagonists in cancer biology.

Inflammation & Allergy - Drug Targets, 2010
Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth. These various biological effects are mediated through the activation of specific histamine receptors (H1, H2, H3, and H4) that differ in their
B. Blaya, Francesca Nicolau-Galmés, S. Jangi, Idoia Ortega-Martínez, Erika Alonso-Tejerina, J. Burgos-Bretones, G. Pérez-Yarza, A. Asumendi, M. Boyano   +8 more
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H2-Histamine receptor blocking agents in the Zollinger-Ellison syndrome. Experience in seven cases and implications for long-term therapy.

Annals of Internal Medicine, 1977
H2-Histamine receptor blocking agents metiamide and cimetidine were assessed in seven patients with Zollinger-Ellison syndrome (serum gastrin greater than 300 microgram/ml, basal acid output greater than 15 meq/h, ratio of basal acid output to maximal ...
D. McCarthy, E. Olinger, R. May, B. W. Long, J. Gardner   +4 more
semanticscholar   +1 more source

Histamine receptor 2 modifies iNKT cell activity within the inflamed lung

Allergy. European Journal of Allergy and Clinical Immunology, 2017
Ruth Ferstl, R. Frei, Weronika Barcik, Elisa Schiavi, Kerstin Wanke, Mario Ziegler, Noelia Rodriguez-Perez, D. Groeger, Patrycja Konieczna, S. Zeiter, D. Nehrbass, R. Lauener, C. Akdis, Liam O'Mahony   +13 more
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