Results 91 to 100 of about 659,937 (298)

Nothing to sneeze at: Histamine and histamine receptors in oral carcinogenesis [PDF]

, 2020
Oral squamous cell carcinoma (OSCC), the most common oral malignancy, shows an increasing rate of incidence worldwide. In spite of the recent advances in cancer research, OSCC therapy continues to have unfavourable outcomes, and thus, patient’s prognosis
Abdelhakim Salem, Salem, Abdelhakim, Tuula Salo, Salo, Tuula   +3 more
core   +1 more source

Assessing ZIF‐8 Stability for Biomedical Applications Using Fluorescent Probes: Impact of Covalent Conjugation

Chemistry – A European Journal, EarlyView.
Using fluorescein as a probe, we compare PEG (polyethylene glycol) surface coatings of ZIF‐8 (zeolitic imidazolate framework‐8) based on coordinative versus covalent attachment and show that PEG coatings provide only limited protection in phosphate‐buffered saline.
Michael B. Stammler, Hana Bunzen
wiley   +1 more source

Effects of Histamine and H1- and H2-Receptor Blocker on Food Intake, Food Passage Rate and in situ Nutrient Uptake from the Small Intestine of Chicken (Gallus domestics)

The Journal of Poultry Science, 2007
To implicate histamine and its receptors in feed intake and nutrient transport, White Leghorn cockerels of the same age and body weight were grouped randomly into six groups.
Abdul Nasir, Ram P. Moudgal, Narendra B. Singh   +2 more
doaj   +1 more source

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

Increase of human platelet serotonin uptake by atypical histamine receptors

, 1994
Histamine and the guanosine 3',5'-cyclic monophosphate (cGMP)-inducing agent sodium nitroprusside both increased serotonin (5-HT) uptake and cGMP levels in isolated human platelets in vitro.
C. Gespach, M. J. Oset-Gasque, J. M. Launay, V. Mutel, S. Emami, M. Haimart, D. Bondoux   +6 more
core   +1 more source

Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships [PDF]

, 2008
Potent and selective histamine H2 receptor (H2R) agonists are valuable pharmacological tools and might be of therapeutic value as drugs, for example in the treatment of severe congestive heart failure.
Kraus, Anja
core   +1 more source

Human induced pluripotent stem cell‐derived cortical neurons from monozygotic twins with the Gαo1K278del mutation reveal disease mechanisms relevant to GNAO1‐related encephalopathy

Epilepsia, EarlyView.
Abstract Objective Rare de novo variants in GNAO1 cause a severe neurodevelopmental disorder characterized by a heterogenous display of early onset epilepsy, movement abnormalities, and global developmental delay. More than 100 pathogenic variants in GNAO1 have been identified and categorized into four groups according to their protein features.
Maria Sáez González, Kes Kloosterhuis, Jeroen Vreijling, Hailiang Mei, Tom P. Hellings, Davide Pirolli, Anine H. Stam, Arn M. J. M. van den Maagdenberg, Vivi M. Heine, Jean‐Philippe Frimat, Laura A. van de Pol, Frank Baas, Harald M. M. Mikkers   +12 more
wiley   +1 more source

Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia. [PDF]

, 2011
The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of ...
LETHBRIDGE, NATASHA,LOUSIE
core  

Distribution of histamine receptors in isolated canine airways

, 1983
The distribution of histamine receptors was examined in isolated trachealis smooth muscle strips and helical strips of large (5 mm) and small (1.5 mm) intrapulmonary airways.
S. L. Bradley, J. A. Russell
core   +1 more source

Do preclinical seizure models predict success or failure in anti‐seizure drug development? A retrospective analysis of 89 compounds with divergent clinical outcomes for epilepsy

Epilepsia, EarlyView.
Abstract Anti‐seizure medication (ASM) discovery remains a major challenge despite over 30 commercially available options. One persistent obstacle for any promising candidate compound to successfully move from preclinical study to clinical approval has been the ambiguity in preclinical model selection.
Wolfgang Löscher, Melissa Barker‐Haliski   +1 more
wiley   +1 more source