Results 81 to 90 of about 49,567 (254)

Activation of Microglia by Histamine and Substance P

Cellular Physiology and Biochemistry, 2014
Background: Activated microglia perform many of the immune effector functions typically associated with macrophages. However, the regulators involved in microglial activation are not well defined.
Jin Zhu, Chen Qu, Xiang Lu, Shu Zhang
doaj   +1 more source

Dietary fiber‐based oral nanovaccine promotes gut‐to‐nose trafficking of regulatory cells and drives antigen‐specific tolerance to relieve airway allergy

iMeta, EarlyView.
Current therapies for allergic rhinitis primarily provide symptomatic relief but fail to establish durable antigen‐specific immune tolerance. Here, we developed an oral nano‐dietary fiber (NDF) platform that integrates allergen delivery with microbiota‐driven immunomodulation, using dextran as both an antigen carrier and a fermentable substrate for ...
Yuting Qin, Zeming Wang, Yuru Zong, Zefang Lu, Junxiu Liu, Ruifang Zhao, Guangjun Nie, Hanqing Chen   +7 more
wiley   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry. [PDF]

Proc Natl Acad Sci U S A, 2023
Peng JY, Qi ZX, Yan Q, Fan XJ, Shen KL, Huang HW, Lu JH, Wang XQ, Fang XX, Mao L, Ni J, Chen L, Zhuang QX.   +12 more
europepmc   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Reevaluating the rule of two's: Age and epidemiological variations in Meckel's diverticulum

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective To evaluate the clinical characteristics, diagnostic modalities, and age‐related variation of Meckel's diverticulum (MD) using data from a nationwide pediatric inpatient database and a single‐center institutional cohort. Methods The Kids' Inpatient Database (KID) for 2016 and 2019 was queried for patients with a principal diagnosis ...
Ashley Polachek, Megha S. Mehta, Ahmed Shalaby, Aamirah Vadsariya, Wenjing Zong, David M. Troendle   +5 more
wiley   +1 more source

Detection of histamine receptors on mouse oocytes and their involvement in fertilization potential. [PDF]

Vet Res Forum, 2022
Yusoff M, Hashim NH, Mohd-Yusuf Y.
europepmc   +1 more source

Phenolic composition and multi‐target bioactivities of Globularia alypum extracts across seasons

JSFA reports, EarlyView.
Abstract Background This study investigates the influence of seasonal variation on the phytochemical profile and biofunctional activities of ethanolic leaf extracts from Globularia alypum. Leaves collected across four seasons were extracted with a hydroethanolic solvent (80:20, v/v) and analyzed by LC‐ESI‐MS/MS.
Mohammed Messaoudi, Khalil Guelift, Mokhtar Benmohamed, Khaled Kherraz, Latifa Khattabi, Afaf Khadra Bendrihem, Khaled Aggoun, Barbara Sawicka, Lilya Harchaoui, Mohamed Amine Ferhat, Salah Neghmouche Nacer, Stefania Garzoli   +11 more
wiley   +1 more source

Pharmacotherapy of Itch-Antihistamines and Histamine Receptors as G Protein-Coupled Receptors. [PDF]

Int J Mol Sci, 2022
Fukasawa T, Yoshizaki-Ogawa A, Enomoto A, Miyagawa K, Sato S, Yoshizaki A.   +5 more
europepmc   +1 more source

Hell's Itch: A Self‐Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a severely distressing dermatological condition characterized by the onset of incessant itching and intolerable pain 2–3 days post‐sunburn. It is underdiagnosed and underreported, and no definitive management framework has yet been developed.
Kai Peter Moors, Willem I. Visser
wiley   +1 more source