Results 61 to 70 of about 53,829 (294)
Histamine in cancer immunology and immunotherapy. Current status and new perspectives
Pharmacology Research & Perspectives, 2021 Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront
María de la Paz Sarasola +3 more
doaj +1 more source
Histamine: A Mediator of Intestinal Disorders—A Review
Metabolites, 2022 Within the gastrointestinal tract, histamine is present at relatively high concentrations, especially during inflammatory processes. Histamine is a biogenic amine with numerous effects on many cell types, mediated by the activation of its four different ...
Sylwia Smolinska +3 more
doaj +1 more source
The Professional Medical Journal, 2010 Objective: This research work deals with the mechanism of action involved in determining the therapeutic potential of histamine and its blockers in gastrointestinal motility. Study Design: Rabbits of equal weights were used in this study. They were brought from the animal house of BMSI, sacrificed in the Pharmacology Research laboratory.
AFTAB TURABI +3 more
openaire +2 more sources
, 2007 The present study was designed to explore the expression and distribution of histamine H3 and H4 receptors within the rat gastric fundus by immunohistochemistry using our unique immunological probes.
SHENTON F. C. +7 more
core +1 more source
Advanced Science, EarlyView.Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen +8 more
wiley +1 more source
The Histamine H4 Receptor: From Orphan to the Clinic
Frontiers in Pharmacology, 2015 The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus ...
Robin L. Thurmond
doaj +1 more source
Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. [PDF]
PLoS ONE, 2012 BACKGROUND:Histamine is detected in high concentrations in the airways during an allergic asthma response. In a murine model of allergic asthma, JNJ 7777120, an antagonist at the histamine H(4) receptor, reduces asthmatic symptoms, while the histamine H ...
Silke Beermann +4 more
doaj +1 more source
Reprogramming the Immune Landscape of Inflammatory Breast Cancer
Advanced Science, EarlyView.Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez +3 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 1997 The possible role of histamine receptors in the hippocampal formation on the exploratory motivation and emotionality of the rat was studied. An elevated asymmetric plus-maze composed of 4 different arms (no walls, single high wall, high and low walls and
M.B. Ruarte, A.G. Orofino, E.O. Alvarez
doaj +1 more source
Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia. [PDF]
, 2011 The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of ...
LETHBRIDGE, NATASHA,LOUSIE
core