Results 61 to 70 of about 659,937 (298)

Histamine in cancer immunology and immunotherapy. Current status and new perspectives

Pharmacology Research & Perspectives, 2021
Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront
María de la Paz Sarasola, Mónica A. Táquez Delgado, Melisa B. Nicoud, Vanina A. Medina   +3 more
doaj   +1 more source

Histamine: A Mediator of Intestinal Disorders—A Review

Metabolites, 2022
Within the gastrointestinal tract, histamine is present at relatively high concentrations, especially during inflammatory processes. Histamine is a biogenic amine with numerous effects on many cell types, mediated by the activation of its four different ...
Sylwia Smolinska, Ewa Winiarska, Anna Globinska, Marek Jutel   +3 more
doaj   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Hippocampal histamine receptors and conflictive exploration in the rat: studies using the elevated asymmetric plus-maze

Brazilian Journal of Medical and Biological Research, 1997
The possible role of histamine receptors in the hippocampal formation on the exploratory motivation and emotionality of the rat was studied. An elevated asymmetric plus-maze composed of 4 different arms (no walls, single high wall, high and low walls and
M.B. Ruarte, A.G. Orofino, E.O. Alvarez
doaj   +1 more source

Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. [PDF]

PLoS ONE, 2012
BACKGROUND:Histamine is detected in high concentrations in the airways during an allergic asthma response. In a murine model of allergic asthma, JNJ 7777120, an antagonist at the histamine H(4) receptor, reduces asthmatic symptoms, while the histamine H ...
Silke Beermann, Silke Glage, Danny Jonigk, Roland Seifert, Detlef Neumann   +4 more
doaj   +1 more source

An improved method for the determination of histamine release in man: its application in studies with propanidid and thiopentone [PDF]

, 1972
Histamine release by propanidid and thiopentone was demonstrated with the use of a highly sensitive and specific method for determining histamine in human plasma. 5 min after i.v.
Lorenz, Wilfried, Doenicke, A., Hutzel, M., Geesing, H., Kusche, J., Meyer, R., Barth, H., Reimann, H. J., Weissenbacher, B.   +8 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

HISTAMINE RECEPTORS

The Professional Medical Journal, 2010
Objective: This research work deals with the mechanism of action involved in determining the therapeutic potential of histamine and its blockers in gastrointestinal motility. Study Design: Rabbits of equal weights were used in this study. They were brought from the animal house of BMSI, sacrificed in the Pharmacology Research laboratory.
AFTAB TURABI, GHULAM ALI ASGHAR QURESHI, Muhammad ZIAULLAH, S. Saud Hasan   +3 more
openaire   +2 more sources

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

ANTI-INFLAMMATORY AND ANTI-ALLERGIC FEATURES OF ANTIBODIES TO HISTAMINE IN RELEASE-ACTIVE FORM: REVIEW OF EXPERIMENTAL AND CLINICAL RESEARCHES

Детские инфекции (Москва), 2015
Preclinical and clinical studies of medical preparations (rengalin, ergoferon) containing release-active (P-A) antibodies to histamine confirmed their ability to provide anti-inflammatory and anti-allergic effect.
E. S. Zhavbert, Yu. L. Dugina, O. I. Epshtein   +2 more
doaj   +1 more source