Results 201 to 210 of about 53,829 (294)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H₂ Histamine Receptors. [PDF]

Prev Nutr Food Sci, 2019
Kim JY, Jang SS, Lee JL, Sim JH, Shim JJ.   +4 more
europepmc   +1 more source

Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target

Allergy, EarlyView.
A. Weingaertner, T. Eiwegger
wiley   +1 more source

Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli   +10 more
wiley   +1 more source

Involvement of histamine H1 and H4 receptors in a murine model of acute skin inflammation and pruritus

, 2014
GRANDI, Daniela, ADAMI, Maristella, MICHELONI, Cristina, CORUZZI, Gabriella, PELLACANI, Claudia   +4 more
core  

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Histamine Receptors in the Cross-Talk between Periphery and Brain. [PDF]

Int J Neuropsychopharmacol, 2017
Lindskog M.
europepmc   +1 more source

Antimicrobial prescribing guidelines for feedlot cattle

Australian Veterinary Journal, EarlyView.
P Cusack, T Batterham, SW Page, GF Browning, JM Norris   +4 more
wiley   +1 more source

Rebound Pruritus and Urticaria After Discontinuation of Chronic Antihistamine Use—A Scoping Review

Clinical &Experimental Allergy, EarlyView.
Rebound pruritus and urticaria have been reported after discontinuation of chronic cetirizine or levocetirizine use only. Symptoms typically occur within 0.5–5 days after stopping therapy and appear more frequently reported in female patients. Re‐initiation of antihistamines is the most commonly effective management strategy, highlighting the need for ...
Jun Jie Benjamin Seng, Prawira Oka, Ngiap Chuan Tan   +2 more
wiley   +1 more source

Impact of Biologics on Oscillometry Defined Small Airway Dysfunction in Uncontrolled Asthma

Clinical &Experimental Allergy, EarlyView.
Forced oscillometry technique defined small airways dysfunction as a treatable trait in asthma. Monoclonal antibodies can improve small airways dysfunction, but their effects vary by mechanism of action. ABSTRACT Small airways dysfunction (SAD) is a recognised treatable trait within severe asthma, associated with worse symptom control and increased ...
Robert Greig, Philipp Suter, Rory Chan, Brian Lipworth   +3 more
wiley   +1 more source