Results 241 to 250 of about 53,829 (294)

Histamine Receptor Assays

Current Protocols in Pharmacology, 2001
AbstractThis unit describes three standard in vitro bioassays for studying histamine H1, H2 and H3 receptors in isolated intact tissues removed from the guinea pig. Both the H1 and H3 receptor assays are based on preparations of the ileum, whereas the spontaneously beating right atrium assay is used for the H2‐receptor.This unit describes three ...
N P, Shankley, M F, Morton, G F, Watt
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Histamine Receptors in the Brain

Allergy and Asthma Proceedings, 1985
In mammalian brain, neuronal histamine is likely to act as a neurotransmitter and is recognized by the two classes of histamine receptors (H1 and H2) previously characterized in peripheral organs. Cerebral H1 receptors can be selectively labeled by a tritiated antagonist mepyramine, in particulate fractions or in the living animal.
M, Garbarg, J C, Schwartz
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Histamine and Histamine Receptors in Allergic Dermatitis

2016
In this chapter we will first introduce the pathophysiological process of several skin diseases including allergic dermatitis, a common skin disease, including chronic allergic contact dermatitis (CACD), and atopic dermatitis (AD). In CACD and AD patients, repeated skin exposure to antigens contributes to the development of chronic eczematous lesions ...
Hiroshi, Ohtsu, Masahiro, Seike
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Histamine and Histamine Receptor Antagonists in Cancer Biology

Inflammation & Allergy - Drug Targets, 2010
Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth. These various biological effects are mediated through the activation of specific histamine receptors (H1, H2, H3, and H4) that differ in their tissue expression patterns and functions.
Bruno, Blaya, Francesca, Nicolau-Galmés, Shawkat M, Jangi, Idoia, Ortega-Martínez, Erika, Alonso-Tejerina, Juan, Burgos-Bretones, Gorka, Pérez-Yarza, Aintzane, Asumendi, María D, Boyano   +8 more
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Histamine, histamine receptors and their role in immune pathology

Clinical & Experimental Allergy, 2009
SummaryThe important roles of histamine in body physiology and various pathologic events have been well established, whereas new and exciting findings are still being uncovered. Histamine is not only the major mediator of the acute inflammatory and immediate hypersensitivity responses, but has also been demonstrated to affect chronic inflammation and ...
Jutel, M, Akdis, M, Akdis, C A
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Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitis

Allergy: European Journal of Allergy and Clinical Immunology, 2011
BACKGROUND: While it is known that histamine is the primary mediator of ocular allergy, the presence and distribution of histamine receptors are not well documented in the human eye.
Andrea Leonardi, Antonino Di Stefano, Paola Brun   +2 more
exaly   +2 more sources

Histamine Receptors in the Lung

Allergy and Asthma Proceedings, 1987
The availability of specific histamine receptor antagonists has provided evidence that human airways have both H1 and H2 receptors. H1 receptors, which mediate bronchoconstriction, predominate. H1 receptor antagonism can produce significant bronchodilatation in some asthmatics, block bronchoconstriction induced by antigen and histamine inhalation ...
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Histamine Receptors in the Lung

1991
Histamine, which has long been implicated as a mediator of allergic airway disease, has multiple effects on airways which are mediated by at least three histamine receptors. H1-receptors mediate bronchoconstriction, vasoconstriction and dilatation, microvascular leak and activation of sensory nerves.
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Histamine receptors are hot in immunopharmacology

European Journal of Pharmacology, 2006
In addition to its well-characterized effects in the acute allergic inflammatory responses, histamine has been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. Histamine can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization, and ...
Cezmi A, Akdis, F Estelle R, Simons
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The new biology of histamine receptors

Current Allergy and Asthma Reports, 2008
The physiologic functions of histamine have been recognized for more than 100 years, yet new roles are still being uncovered. Most importantly, a newly discovered receptor of the amine has helped refine our understanding of histamine. This new receptor, the histamine H4 receptor (H4R), has a higher affinity for histamine compared with the histamine H1 ...
Jing-Feng, Huang, Robin L, Thurmond
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