Results 251 to 260 of about 53,829 (294)
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Histamine H3 Receptor Agonists
Mini-Reviews in Medicinal Chemistry, 2004The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
I J P, De Esch, K J, Belzar
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Histamine H4 receptor agonists
Bioorganic & Medicinal Chemistry Letters, 2010Since its discovery 10 years ago the histamine H(4) receptor (H(4)R) has attracted attention as a potential drug target, for instance, for the treatment of inflammatory and allergic diseases. Potent and selective ligands including agonists are required as pharmacological tools to study the role of the H(4)R in vitro and in vivo.
Patrick, Igel +2 more
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Histamine Receptors in the Synovial Microcirculation
European Journal of Clinical Investigation, 1975Abstract. This study was designed to investigate the respective roles of H1 and H2 receptors in the control of the microcirculation by examining the effectiveness of the H2 receptor antagonist metiamide (Met.) and Hj receptor antagonist mepyramine is blocking the action of histamine on synovial perfusion. Synovial perfusion was monitored indirectly by
D. M. Grennan +5 more
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2002
Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
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Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
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Histamine H3-receptor isoforms
Inflammation Research, 2004Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor.
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Histamine H2-receptor antagonists
Baillière's Clinical Gastroenterology, 1988The first histamine H2-receptor antagonists were developed in the early 1970s, and they have a dominant role in today's management of peptic ulceration. The original regimens using either cimetidine or ranitidine attempted to control acidity across the 24 hours, but more 'modern' regimens use a large single dose of the H2-blocker in the evening, which ...
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Histamine and Histamine Receptors in Health and Disease
2017Part 1: New Analytical tools.- Histamine and histamine receptors: State of the art.- Mass-spectrometric methods for the detection of histamine and histamine metabolites.- Fluorescent ligands and radioligands for the analysis of histamine receptors.- Molecular analysis of histamine receptors: Structural analysis of the histamine H1-receptor.- Molecular ...
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