Results 81 to 90 of about 147,237 (374)

Effect of histamine on the electric activities of cerebellar Purkinje cell [PDF]

open access: yesarXiv, 1999
The effect of histamine (HA) on the electric activities of Purkinje cell (PC) is studied on the cerebellum slice. We find that: (1) HA's main effect on PC is excitative (72.9%); there are also a small amount of PC showing inhibitive (10.2%) or no (16.9%) response to HA.
arxiv  

Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology

open access: yesChemBioChem, EarlyView.
This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda   +2 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi   +6 more
wiley   +1 more source

Role of protein phosphatases inhibitors on the histamine release and the functional desensitization in human lung mast cells

open access: yesJournal of Research in Medical Sciences, 2014
Background: The β2-adrenoceptor agonist, isoprenaline, is an effective inhibitor of histamine release from human lung mast cells (HLMC). Since phosphorylations of the β2-adrenoceptors are probably important in inducing desensitization, we sought to ...
Reza Bastan   +4 more
doaj  

From Allergy to Angina: A Unique Presentation of Kounis Syndrome

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Kounis syndrome (KS) is a rare condition characterized by acute coronary syndrome (ACS) triggered by an allergic reaction. This report presents a case of high‐risk ACS associated with a food allergy. A 53‐year‐old male with no prior medical history presented to the emergency department with itching, facial swelling, chest tightness, shortness ...
Momen Ali   +3 more
wiley   +1 more source

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

open access: yes, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Becker, Bernhard F.   +4 more
core   +1 more source

Inhibition of NO-synthase and degranulation of rat omental mast cells in vitro

open access: yesMediators of Inflammation, 1996
Mast cell amines, platelet-activating factor (PAF), thromboxanes and leukotrienes have been shown to be released during nitric oxide-synthase inhibition in the rat intestine.
A. M. Northover, B. J. Northover
doaj   +1 more source

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

open access: yesFrontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi   +7 more
doaj   +1 more source

Prospects of using Antagonist Histamine H2-Receptor (Cimetidinum) as Adjuvant for Melanoma Biotherapy Treatment [PDF]

open access: yesInternational Journal of Immunopathology, Allergology, Infectology 2010, #4: P. 42-51, 2011
Improvement of anti-tumor biotherapy effectiveness by modification of immune response with histamine H2 receptor Cimetidinum (CM) was studied using the experimental murine model of B16 F10 melanoma in vivo. It is shown that skin melanoma biotherapy by antitumor whole-cell GM-CSF-producing vaccine with the addition of CM (in dose of 25 mg/kg, daily for ...
arxiv  

Modeling Reservoir Release Using Pseudo-Prospective Learning and Physical Simulations to Predict Water Temperature [PDF]

open access: yesarXiv, 2022
This paper proposes a new data-driven method for predicting water temperature in stream networks with reservoirs. The water flows released from reservoirs greatly affect the water temperature of downstream river segments. However, the information of released water flow is often not available for many reservoirs, which makes it difficult for data-driven
arxiv  

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