Results 61 to 70 of about 66,422 (214)

Contribution of Histamine to Nociceptive Behaviors Induced by Intrathecally Administered Cholecystokinin-8

Frontiers in Pharmacology, 2020
The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi, Chizuko Watanabe, Soh Katsuyama, Yasuyuki Agatsuma, Damiana Scuteri, Giacinto Bagetta, Tsukasa Sakurada, Shinobu Sakurada   +7 more
doaj   +1 more source

Histamine H3 Receptor Heterogeneity in the Central Nervous System in Aging and Dementia. [PDF]

, 2011
The histamine H3R is a classic G-protein coupled receptor and is a potential therapeutic target for a number of central nervous system pathologies. Major pharmacological heterogeneity between and within species has hindered the clinical development of ...
LETHBRIDGE, NATASHA,LOUSIE
core  

Histamine stimulates human microglia to alter cellular prion protein expression via the HRH2 histamine receptor

Scientific Reports
Although the cellular prion protein (PrPC) has been evolutionarily conserved, the role of this protein remains elusive. Recent evidence indicates that PrPC may be involved in neuroinflammation and the immune response in the brain, and its expression may ...
Marcus Pehar, Melissa Hewitt, Ashley Wagner, Jagdeep K. Sandhu, Aria Khalili, Xinyu Wang, Jae-Young Cho, Valerie L. Sim, Marianna Kulka   +8 more
doaj   +1 more source

Anti-allergic Inflammatory Effects of Cyanogenic and Phenolic Glycosides from the Seed of

Natural Product Communications, 2013
A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides ( 1–3 ) and other phenolic compounds ( 4–8 ).
Geum Jin Kim, Hyun Gyu Choi, Ji Hyang Kim, Sang Hyun Kim, Jeong Ah Kim, Seung Ho Lee   +5 more
doaj   +1 more source

Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation.

PLoS ONE, 2012
IntroductionChronic mast cell activation is a characteristic feature of asthma. BEAS-2B human airway epithelial cells (AEC) profoundly inhibit both constitutive and IgE-dependent human lung mast cell (HLMC) histamine release. The aim of this study was to
Neil Martin, Andrew Ruddick, Greer K Arthur, Heidi Wan, Lucy Woodman, Christopher E Brightling, Don J L Jones, Ian D Pavord, Peter Bradding   +8 more
doaj   +1 more source

Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1

, 2013
PMCID: PMC3601088This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Samia Yazid, Solito E., Sinniah Ajantha, Flower R. J., Egle Solito, Yazid S., Solito, E, Rod J Flower, Sinniah, A, Sinniah A., Calder V., Yazid Samia, Ajantha Sinniah, Calder Virginia, Flower Rod J., Flower, RJ, Yazid, S, Virginia Calder, Calder, V, Solito Egle, Rod J. Flower   +20 more
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IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

Mediators of Inflammation, 1998
The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is
U. Westin, E. Lundberg, K. Ohlsson
doaj   +1 more source

Molecular analysis of the histamine H3-receptor

, 2010
The histamine H3 receptor (H3R) is a biogenic amine receptor that belongs to family I of G protein-coupled receptors (GPCRs). During the past two decades, the H3R has gained much interest in academia and industry.
Schnell, David
core   +1 more source

抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化

, 1992
Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood.
Tanizaki, Yoshiro, Kimura, Ikuro
core   +1 more source

Different hypersensitivities against homologous proteins of MGL_1304 in patients with atopic dermatitis

Allergology International, 2018
Background: Atopic dermatitis (AD) is exacerbated by sweating, and the skin of most patients with AD are resided by Malassezia (M.) fungi. Recently, MGL_1304 produced by Malassezia globosa was identified as the major histamine releasing antigen in human ...
Takuma Kohsaka, Takaaki Hiragun, Kaori Ishii, Makiko Hiragun, Akiko Kamegashira, Michihiro Hide   +5 more
doaj   +1 more source