Results 1 to 10 of about 80,619 (308)

Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis

Allergology International, 2021
Background: Although basophils are considered to play an important role for maintenance of type 2 inflammation in atopic dermatitis (AD), studies on basophils in AD patients are limited.
Shinya Imamura, Ken Washio, Mayuko Mizuno, Yoshiko Oda, Atsushi Fukunaga, Chikako Nishigori   +5 more
doaj   +1 more source

Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils

Nature Communications, 2023
Basophils are the rarest granulocytes and are recognized as critical cells for type 2 immune responses. However, their differentiation pathway remains to be fully elucidated.
Kensuke Miyake, Junya Ito, Jun Nakabayashi, Shigeyuki Shichino, Kenji Ishiwata, Hajime Karasuyama   +5 more
doaj   +1 more source

IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?

Antibodies, 2020
Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning usually before one year of age. It is associated with the emergence of allergen-specific IgE, but also with autoreactive IgE, whose function remain elusive.
Christophe Pellefigues
doaj   +1 more source

The roles of basophils in mediating the immune responses

European Journal of Inflammation, 2021
Basophils are the rarest blood cell population and have not been extensively studied. Our understanding of the functions of basophils is limited to their roles as the main effector cells in hypersensitivity reactions.
Na Zhang, Ze-Ming Zhang, Xiao-Fei Wang
doaj   +1 more source

Basophils as a potential marker of lupus nephritis by flow cytometry

Future Science OA, 2021
Objective: To establish a convenient and simple flow cytometry immunophenotyping panel to explore immune cellular alterations and potential cellular biomarkers in systemic lupus erythematosus.
Yanni Jiang, Jin Chen, Yi Zhao, Yi Liu, Hong Xu, Xianming Mo   +5 more
doaj   +1 more source

Is There a Role for Basophils in Cancer?

Frontiers in Immunology, 2020
Basophils were identified in human peripheral blood by Paul Ehrlich over 140 years ago. Human basophils represent <1% of peripheral blood leukocytes.
Giancarlo Marone, Giancarlo Marone, John T. Schroeder, Fabrizio Mattei, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Adriana Rosa Gambardella, Remo Poto, Remo Poto, Amato de Paulis, Amato de Paulis, Amato de Paulis, Giovanna Schiavoni, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +18 more
doaj   +1 more source

Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid

Biomolecules, 2023
Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230.
Maren M. Limberg, Tobias Weihrauch, Natalie Gray, Nancy Ernst, Karin Hartmann, Ulrike Raap   +5 more
doaj   +1 more source

IgE-dependent human basophil responses are inversely associated with the sarcoplasmic reticulum Ca2+-ATPase (SERCA)

Frontiers in Immunology, 2023
Basophils crucially contribute to allergies and other Th2-driven diseases by rapidly releasing inflammatory and immunomodulatory mediators following high-affinity IgE-receptor crosslinking.
Anette T. Hansen Selnø, Vadim V. Sumbayev, Bernhard F. Gibbs, Bernhard F. Gibbs   +3 more
doaj   +1 more source

Remibrutinib inhibits hives effector cells stimulated by serum from chronic urticaria patients independently of FcεR1 expression level and omalizumab clinical response

Clinical and Translational Allergy, 2023
Background Despite advances in the treatment of chronic urticaria, in a significant percentage of the patients symptoms are not fully controlled with conventional approaches.
Ramón Gimeno, Clara Ribas‐Llauradó, David Pesque, Evelyn Andrades, Bruno Cenni, Barbara Ambros, Ramon Pujol, Ana M. Giménez‐Arnau   +7 more
doaj   +1 more source

Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease

Diagnostics, 2023
Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors.
Giuseppe Brescia, Cristoforo Fabbris, Leonardo Calvanese, Luigia Bandolin, Barbara Pedruzzi, Valerio Maria Di Pasquale Fiasca, Silvia Marciani, Francesca Mularoni, Fabio Degli Esposti Pallotti, Michael Negrisolo, Giacomo Spinato, Anna Chiara Frigo, Gino Marioni   +12 more
doaj   +1 more source