Results 11 to 20 of about 56,684 (297)
Basophils Orchestrating Eosinophils’ Chemotaxis and Function in Allergic Inflammation [PDF]
Cells, 2021 Eosinophils are well known to contribute significantly to Th2 immunity, such as allergic inflammations. Although basophils have often not been considered in the pathogenicity of allergic dermatitis and asthma, their role in Th2 immunity has become ...
Joseena Iype, Michaela Fux
doaj +3 more sources
Basophils from allergy to cancer
Frontiers in Immunology, 2022 Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating leukocytes. While this scarcity long hampered basophil studies, innovations during the past 30 years, beginning with their isolation and more recently in the ...
Remo Poto +15 more
doaj +2 more sources
CD25 as a unique marker on human basophils in stable-mildly symptomatic allergic asthma [PDF]
Frontiers in Immunology, 2023 BackgroundBasophils in acute asthma exacerbation are activated as evidenced by their increased expression levels of activation markers such as CD203c and CD63.
Joseena Iype +7 more
doaj +3 more sources
Basophils beyond allergic and parasitic diseases
Frontiers in Immunology, 2023 Basophils bind IgE via FcεRI-αβγ2, which they uniquely share only with mast cells. In doing so, they can rapidly release mediators that are hallmark of allergic disease.
Remo Poto +18 more
doaj +2 more sources
Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis [PDF]
Biochemistry and Biophysics Reports, 2017 Basophils, which are the rarest granulocytes, play crucial roles in protective immunity against parasites and development of allergic disorders. Although immunoglobulin (Ig)E-dependent responses via receptor for IgE (FcεRI) in basophils have been ...
Takeshi Nakamura +6 more
doaj +3 more sources
Emerging roles of basophils in allergic inflammation
Allergology International, 2017 Basophils have long been neglected in immunological studies because they were regarded as only minor relatives of mast cells. However, recent advances in analytical tools for basophils have clarified the non-redundant roles of basophils in allergic ...
Kensuke Miyake, Hajime Karasuyama
doaj +2 more sources
IL-1β promotes immunoregulatory responses in human blood basophils. [PDF]
, 2021 Human basophils are essential effector cells of chronic allergic inflammation. IL-1 family cytokines such as interleukin (IL)-33 and IL-1β are elevated in serum and bronchoalveolar lavage fluid of allergic asthmatics.
Fux, Michaela +9 more
core +1 more source
Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid
Biomolecules, 2023 Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230.
Maren M. Limberg +5 more
doaj +1 more source
Journal of Clinical Investigation, 1980 Factors influencing basophil production from the bone marrow of ovalbumin (OA)-sensitized guinea pigs have been examined in vitro. Autologous co-cultures of marrow and spleen cells from OA-immune animals contained significantly higher numbers of basophils after 7 d of liquid culture in the presence of OA, compared with control co-cultures or with ...
J A, Denburg, M, Davison, J, Bienenstock
openaire +2 more sources
Frontiers in Immunology, 2023 Basophils crucially contribute to allergies and other Th2-driven diseases by rapidly releasing inflammatory and immunomodulatory mediators following high-affinity IgE-receptor crosslinking.
Anette T. Hansen Selnø +3 more
doaj +1 more source