Results 1 to 10 of about 163,247 (160)
The Junction of Allergic Inflammation and Atherosclerosis: Pathways and Clinical Implications-A Review. [PDF]
Life (Basel)Background: Cardiovascular disorders, especially atherosclerosis, have been associated with allergic inflammation. In addition to traditional inflammatory responses, there is evidence that the development and instability of coronary artery plaque may be ...
Valcovici M +9 more
europepmc +2 more sources
Therapeutical Targets in Allergic Inflammation. [PDF]
Biomedicines, 2022 From the discovery of IgE to the in-depth characterization of Th2 cells and ILC2, allergic inflammation has been extensively addressed to find potential therapeutical targets. To date, omalizumab, an anti-IgE monoclonal antibody, and dupilumab, an anti-IL-4 receptor α monoclonal antibody, represent two pillars of biologic therapy of allergic ...
Salvati L +3 more
europepmc +4 more sources
Prostacyclin Regulation of Allergic Inflammation. [PDF]
Biomedicines, 2022 Prostacyclin is a metabolic product of the cyclooxygenase pathway that is constitutively expressed and can be induced during inflammatory conditions. While prostacyclin and its analogs have historically been considered effective vasodilators and used in treating pulmonary hypertension, prostacyclin has demonstrated potent anti-inflammatory effects in ...
Patel K, Peebles RS.
europepmc +4 more sources
Frontiers in Immunology, 2019 The objective of this study was to investigate the relationship between autophagy and allergic inflammation. In vitro allergic inflammation was accompanied by an increased autophagic flux in rat basophilic leukemia (RBL2H3) cells.
Misun Kim +10 more
doaj +3 more sources
Frontiers in Immunology, 2021 The objective of this study was to investigate mechanisms of allergic inflammation both in vitro and in vivo in details. For this, RNA sequencing was performed.
Yoojung Kwon +6 more
doaj +3 more sources
Cysteinyl Leukotrienes in Allergic Inflammation. [PDF]
Annu Rev PatholThe cysteinyl leukotrienes (CysLTs), LTC 4 , LTD 4 , and LTE 4 , are potent lipid mediators derived from arachidonic acid through the 5-lipoxygenase pathway.
Lee M, Boyce JA, Barrett NA.
europepmc +3 more sources
The hyaluronic acid-HDAC3-miRNA network in allergic inflammation
Frontiers in Immunology, 2015 We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI.
Youngmi eKim +4 more
doaj +3 more sources
Depression of Ca<sub>V</sub>1.2 activation and expression in mast cells ameliorates allergic inflammation diseases. [PDF]
J Pharm AnalAllergic inflammation is closely related to the activation of mast cells (MCs), which is regulated by its intracellular Ca2+ level, but the intake and effects of the intracellular Ca2+ remain unclear.
Zhang Y +7 more
europepmc +2 more sources
Emerging roles of basophils in allergic inflammation
Allergology International, 2017 Basophils have long been neglected in immunological studies because they were regarded as only minor relatives of mast cells. However, recent advances in analytical tools for basophils have clarified the non-redundant roles of basophils in allergic ...
Kensuke Miyake, Hajime Karasuyama
doaj +3 more sources
Regulation of Syk activity by antiviral adaptor MAVS in FcεRI signaling pathway
Frontiers in Allergy, 2023 BackgroundMast cells are the major effector cell type for IgE-mediated allergic reactions. Recent studies revealed a role for mast cells in orchestrating the host response to viral infections.ObjectiveWe studied the relationship between FcεRI (high ...
Yuko Kawakami +7 more
doaj +1 more source