New Insights into the Roles for Basophils in Acute and Chronic Allergy
Allergology International, 2009 Basophils represent less than 1% of peripheral blood leukocytes. They are often recruited to the site of allergic inflammation, albeit in small numbers.
Kaori Mukai +3 more
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Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]
, 2015 Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam +8 more
core +3 more sources
Basophils beyond allergic and parasitic diseases
Frontiers in Immunology, 2023 Basophils bind IgE via FcεRI-αβγ2, which they uniquely share only with mast cells. In doing so, they can rapidly release mediators that are hallmark of allergic disease.
Remo Poto +18 more
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Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]
, 2018 The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda +7 more
core +1 more source
Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis
Biochemistry and Biophysics Reports, 2017 Basophils, which are the rarest granulocytes, play crucial roles in protective immunity against parasites and development of allergic disorders. Although immunoglobulin (Ig)E-dependent responses via receptor for IgE (FcεRI) in basophils have been ...
Takeshi Nakamura +6 more
doaj +1 more source
Clinical and Translational Allergy, 2022 Background IgE and high‐affinity IgE receptor (FcεRI) expression on basophils have been scarcely explored in patients with chronic inducible urticaria (CIndU).
Ana M. Giménez‐Arnau +5 more
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The Major Soybean Allergen Gly m Bd 28K Induces Hypersensitivity Reactions in Mice Sensitized to Cow's Milk Proteins [PDF]
, 2016 Reactions to soy have been reported in a proportion of patients with IgE-mediated cow’s milk allergy (CMA). In this work, we analyzed if Gly m Bd 28K/P28, one of the major soybean allergens, is a cross-reactive allergen with cow milk proteins (CMP).
Candreva, Ángela María +5 more
core +2 more sources
UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils
Allergology International, 2017 Background: P2Y purinergic receptors (P2YR) are G protein-coupled receptors that are stimulated by extracellular nucleotides. They mediate cellular effects by regulating cAMP production, protein kinase C activation, inositol trisphosphate generation, and
Manabu Nakano +7 more
doaj +1 more source
The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils
Frontiers in Immunology, 2019 Basophils are granulocytes involved in parasite immunity and allergic diseases, known for their potent secretion of type 2 cytokines. Identifying their functions has proven to be controversial due to their relative rarity and their complex lineage ...
Christophe Pellefigues +9 more
doaj +1 more source
Basophils Orchestrating Eosinophils’ Chemotaxis and Function in Allergic Inflammation
Cells, 2021 Eosinophils are well known to contribute significantly to Th2 immunity, such as allergic inflammations. Although basophils have often not been considered in the pathogenicity of allergic dermatitis and asthma, their role in Th2 immunity has become ...
Joseena Iype, Michaela Fux
doaj +1 more source