Results 231 to 240 of about 265,522 (247)

Integrating computational simulation and high-throughput screening for the development of robust ultra-high concentration formulation of IgG1 antibody. [PDF]

MAbs
Lyu C, Lu S, Yin Y, Li H, Xing D, Lu Y, Zheng S, Zhang Q, Gao L, Xu S, Zou Q, Liu F, Zhang J, Kang Y.   +13 more
europepmc   +1 more source

An In Vitro and In Vivo Assessment of the Genotoxic Potential of Maizinol (UP165), a Zea mays Leaf Extract

Journal of Applied Toxicology, EarlyView.
ABSTRACT Benzoxazinoids are secondary metabolites produced in monocotyledons and some dicotyledons from the Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae families. Benzoxazinoids are commonly consumed in bread and cereal products that have been ingested for decades, which supports the safe use of benzoxazinoids as food ...
J. Kyle Weston, Barry S. Lynch, James A. Akingbasote   +2 more
wiley   +1 more source

Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study. [PDF]

Amino Acids
Świątkiewicz M, Lejczak A, Foltyński P, Grieb P.   +3 more
europepmc   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

The Journal of Clinical Pharmacology, EarlyView.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Nancy Agrawal, Janet Hammond   +9 more
wiley   +1 more source

Genetic incorporation of diverse non-canonical amino acids for histidine substitution

Perdiguero AN, Fischer S, Lischke AR, Manser BP, Liang AD.   +4 more
europepmc   +1 more source

MediaAssist: database to support the design and optimization of cell culture medium. [PDF]

Nucleic Acids Res
Thakar K, Madhugiri I, Gadgil C, Gadgil M.   +3 more
europepmc   +1 more source

A Phase 1 Study of the Pharmacokinetics, Safety, and Tolerability of Posdinemab (JNJ‐63733657) in Healthy Chinese Adults

The Journal of Clinical Pharmacology, EarlyView.
Abstract Posdinemab, a humanized immunoglobulin G1/κ monoclonal antibody, binds with high affinity to phosphorylated tau protein which is associated with Alzheimer's disease (AD) pathophysiology. Posdinemab reduced tau seeding in murine models and was well tolerated in Phase‐1 clinical studies.
Fangfang Wang, Juanfang Liu, Daisy Bai, Lingjue Li, Maggie Fedgchin, David Henley, Haiyan Li, Fan Zhang   +7 more
wiley   +1 more source

Aromatic amino acid-metal ion interactions: comparative effects of alkali and Zn²⁺ on acidity and coordination behavior via QM studies. [PDF]

Amino Acids
Kalhor S, Fattahi A.
europepmc   +1 more source

Nonresonant Surface‐Enhanced Hyper Raman Scattering of Aromatic Amino Acids on Gold Nanoparticles

Journal of Raman Spectroscopy, EarlyView.
The surface‐enhanced hyper Raman spectra of the three aromatic amino acids phenylalanine, tryptophan, and tyrosine, obtained with nonresonant excitation at a wavelength of 1064 nm, are reported. The data are discussed in the context of the interaction of the molecules with two gold nanoparticle plasmonic substrates, as well as intermolecular ...
Fariha Binte Rahman, Janina Kneipp
wiley   +1 more source

Natural Mutation in Naked Mole-Rat UCP1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis. [PDF]

Acta Physiol (Oxf)
Gaudry MJ, Bundgaard A, Kutschke M, Ostatek K, Dela Rosa MAS, Crichton PG, Reznick J, Jastroch M.   +7 more
europepmc   +1 more source