Results 241 to 250 of about 228,380 (298)

Balancing Doses of EL222 and Light Improves Optogenetic Induction of Protein Production in Komagataella phaffii

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Komagataella phaffii, also known as Pichia pastoris, is a powerful host for recombinant protein production, in part due to its exceptionally strong and tightly controlled PAOX1 promoter. Most K. phaffii bioprocesses for recombinant protein production rely on PAOX1 to achieve dynamic control in two‐phase processes.
Shannon M. Hoffman, Sebastián Espinel‐Ríos, Sarah K. Kwartler, Makoto A. Lalwani, José L. Avalos   +4 more
wiley   +1 more source

Proximity-induced SuFEx increases the potency of cytosolic nucleotidase inhibitors and reveals a rare example of covalently targeted histidine. [PDF]

RSC Chem Biol
Chrominski M, Warminski M, Kozarski M, Kubacka D, Panecka-Hofman J, Spiewla T, Zmudzinski M, Jemeility J, Kowalska J.   +8 more
europepmc   +1 more source

Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT There is increasing interest in the development of intensified processes that can provide significant reductions in manufacturing costs for monoclonal antibody (mAb) products. This study examines the performance of an integrated membrane process that combines single‐pass tangential flow filtration (SPTFF) with high‐performance countercurrent ...
Mirko Minervini, Aylin Mohammadzadehmarandi, Ali Behboudi, Sheldon F. Oppenheim, Andrew L. Zydney   +4 more
wiley   +1 more source

Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety. [PDF]

Sci Rep
Huertas T, Millán D, Fonseca-Benítez AV, Guevara-Pulido J.   +3 more
europepmc   +1 more source

Layered double hydroxides‐based nanozymes for effective biomedical applications: A review and future perspectives

BMEMat, EarlyView.
In this review, we introduced the preparation methods of LDHzymes and discussed their catalytic activity and mechanisms. Subsequently, the applications of LDHzymes in biomedical were discussed. Finally, potential future work on LDHzymes was proposed to better design these new types of nanozymes.
Jiawei Cui, Lu Zhang, Junyi Li, Yue Chen, Sheng Dai, Manfred F. Maitz, Ansha Zhao, Ping Yang   +7 more
wiley   +1 more source

Transcriptome enhanced rice grain metabolic model identifies histidine level as a marker for grain chalkiness. [PDF]

Sci Rep
Chowdhury NB, Chandran AKN, Walia H, Saha R.   +3 more
europepmc   +1 more source

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, EarlyView.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Majority of the erythrocyte binding proteins of the Pvfam "a" family of <i>Plasmodium vivax</i> interact with Basigin to assist parasite entry into the host cell. [PDF]

Front Cell Infect Microbiol
Tripathi M, Santoshi M, Sharma YD, Rathore S.   +3 more
europepmc   +1 more source

Considering the utility of urinary amino acids for early identification of non-diabetic chronic kidney disease. [PDF]

Clin Kidney J
Wu HHL, Cantor D, Chi F, The Nguyen L, Chinnadurai R, Pollock CA, Saad S.   +6 more
europepmc   +1 more source

Constant pH Molecular Dynamics Simulation of pH Effects on Amyloid-β Structure, Dynamics, and Metal-Binding. [PDF]

Chemistry
Albrahadi T, Hureau C, Platts JA.
europepmc   +1 more source