Results 291 to 300 of about 135,820 (362)

Ex Vivo Preservation of Porcine Vascularized Composite Soft Tissue Allografts

open access: yesArtificial Organs, Volume 49, Issue 6, Page 955-966, June 2025.
The aim of this study was to evaluate the effectiveness of ex vivo perfusion (EVP) for vascularized composite tissue preservation. EVP preserved abdominal free flaps for 24 h within physiologic parameters and without development of edema. EVP may extend preservation time and geographic reach for VCAs.
Abigail Meyers   +13 more
wiley   +1 more source

Transfer RNA and small molecule therapeutics for aminoacyl‐tRNA synthetase diseases

open access: yesThe FEBS Journal, Volume 292, Issue 11, Page 2737-2750, June 2025.
Aminoacyl‐tRNA synthetases catalyze the ligation of a specific amino acid to a cognate tRNA—a reaction that lays the foundations for deciphering the genetic code. Pathogenic alleles in these synthetases can lead to dominant or recessive disorders, for which little or no disease‐specific treatments exist.
Tristan N. Samuels   +8 more
wiley   +1 more source

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16

open access: yesThe FEBS Journal, Volume 292, Issue 11, Page 2771-2783, June 2025.
Purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans, but remains poorly understood in metazoan. To investigate the impact of dietary components on purine metabolism and animal growth, we screened the effects of an Escherichia coli single‐gene deletion library on the growth of the nematode ...
Min Feng   +3 more
wiley   +1 more source

PorA of the Type IX Secretion Is a Ligand of the PorXY Two‐Component Regulatory System in Porphyromonas gingivalis

open access: yesMolecular Microbiology, Volume 123, Issue 6, Page 569-585, June 2025.
Porphyromonas gingivalis exports several virulent proteins, including gingipain proteinases, via the type 9 secretion system. Expression of several T9SS component proteins is regulated by the PorA‐PorY‐PoX‐SigP signaling cascade. This study presents a novel role of PorA in the signaling cascade.
Momoko Ito   +9 more
wiley   +1 more source

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