Results 331 to 340 of about 135,820 (362)

Histidine Kinases as Antimicrobial Targets: Prospects and Pitfalls

Mini-Reviews in Medicinal Chemistry, 2007
Histidine kinases are ubiquitous molecular sensors that are used by bacteria to detect and respond to a myriad of environmental signals. They are attractive antimicrobial targets because of their roles in mediating the virulence of pathogenic organisms, as well as the ability of bacteria to resist host defenses and develop resistance to antibiotics. In
Rowland, S. L., King, G. F.
openaire   +4 more sources

A Bioorganometallic Approach to Study Histidine Kinase Autophosphorylations

Chemistry – A European Journal, 2017
AbstractAuto‐phosphorylation of bacterial histidine kinases PhoR, PhoQ, and EnvZ has been investigated using adenosine‐5′‐[γ‐ferrocene] triphosphate (Fc‐ATP) as a cosubstrate for the first time. The study has been carried out in solution and on surface. Results from biochemical multiplex assay and surface electrochemical/optical methods are consistent,
Nan Wang, Zhe She, Zakiyya Ingar, Sanela Martic, Heinz‐Bernhard Kraatz   +4 more
openaire   +3 more sources

Development of a Light-Dependent Protein Histidine Kinase

2019
Phosphorylation plays a critical role in facilitating signal transduction in prokaryotic and eukaryotic organisms. Our study introduces a tool for investigation of signal diffusion in a biochemical regulation network through the design and characterization of a light-stimulated histidine kinase that consists of the LOV domain from YtvA from Bacillus ...
Aleksandra Bury, Klaas J. Hellingwerf
openaire   +3 more sources

Histidine Kinases

2003
Fabiola Janiak-Spens, Ann H. West
  +4 more sources

Protein Histidine Kinase

2003
Karina Chan, Harry R. Matthews
openaire   +3 more sources

Trends in kinase drug discovery: targets, indications and inhibitor design

Nature Reviews Drug Discovery, 2021
Helgi B Schiöth, Misty M Attwood, Stefan Knapp   +2 more
exaly  

Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, 2021
Darren Cross, Pasi A Jänne, Philip Cohen   +2 more
exaly  

Kinase inhibition in autoimmunity and inflammation

Nature Reviews Drug Discovery, 2021
Ali A Zarrin, Bruno Hochhegger, Katherine Bao   +2 more
exaly  

Treatment of renal cell carcinoma: Current status and future directions

Ca-A Cancer Journal for Clinicians, 2017
Pedro Barata, Brian I Rini
exaly  

Lung cancer: New biological insights and recent therapeutic advances

Ca-A Cancer Journal for Clinicians, 2011
Suresh S Ramalingam, Taofeek K Owonikoko, Fadlo R Khuri   +2 more
exaly