Results 1 to 10 of about 41,454 (260)

Histiocytosis

The Lancet, 2021
Histiocytoses constitute a heterogeneous group of rare disorders, characterised by infiltration of almost any organ by myeloid cells with diverse macrophage or dendritic cell phenotypes. Histiocytoses can start at any age. Diagnosis is based on histology in combination with appropriate clinical and radiological findings.
Emile, Jean-François, Cohen-Aubart, Fleur, Collin, Matthew, Fraitag, Sylvie, Idbaih, Ahmed, Abdel-Wahab, Omar, Rollins, Barrett, Donadieu, Jean, Haroche, Julien   +8 more
openaire   +5 more sources

Langerhans Cell Histiocytosis With <i>MAP2K1^E102_I103del</i> Mutation Successfully Treated With Trametinib. [PDF]

EJHaem
ABSTRACT The discovery of the MAPK pathway mutations in lesions of patients with Langerhans cell histiocytosis (LCH) has made targeted therapy an important therapeutic approach for these patients. Theoretically, the RAF‐independent mutation MAP2K1E102_I103del is naturally resistant to allosteric MEK inhibitors.
Lang M, Chang L, Cao XX.
europepmc   +2 more sources

Erdheim-Chester Disease Manifesting Without Long Bone Involvement. [PDF]

Respirol Case Rep
We present an atypical case of Erdheim–Chester Disease (ECD) due to the absence of skeletal involvement despite widespread infiltration of other organs. ABSTRACT Erdheim–Chester Disease (ECD) is an extremely rare, non‐Langerhans cell histiocytosis characterised by the proliferation of foamy histiocytes infiltrating various organs.
Sivasubramanian D, Balasubramanian K, Mohamed Kalifa MRH, Sanil S, Aravind S, Palanisamy NN, Senthilkumar V.   +6 more
europepmc   +2 more sources

Langerhans cell histiocytosis

Indian Journal of Medical Research, 2018
Langerhans cell histiocytosis (LCH) formerly known as pulmonary eosinophilic granuloma is currently regarded by the World Health Organization as a clonal neoplastic proliferation of histiocytes.
Anil S Menon, Manish Kumar
openaire   +4 more sources

Pediatric Cutaneous Anaplastic Lymphoma Kinase-Positive Histiocytosis with DCTN1::ALK Fusion: A Case Report and Literature Search [PDF]

Diagnostics
Background and Clinical Significance: Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a relatively novel entity, affecting single or multiple organ systems; it is characterized by aggregates of neoplastic cells of the histiocytic lineage ...
Kristóf Levente Korpás, Attila Mokánszki, Lívia Beke, Gábor Méhes, Yi-Che Chang Chien   +4 more
doaj   +2 more sources

Histiocytosis-X [PDF]

Proceedings of the Royal Society of Medicine, 1962
J S Pegum, Patricia Wallis
openalex   +3 more sources

Quantitative Brain MRI Analysis in Neurodegenerative Langerhans Cell Histiocytosis. [PDF]

Eur J Neurol
ABSTRACT Background Neurodegenerative Langerhans Cell Histiocytosis (ND‐LCH) is a severe central nervous system involvement complicating LCH. ND‐LCH is characterized by a cerebellar ataxia, pyramidal signs, pseudobulbar palsy, cognitive impairment, and behavioral disturbances.
Baek C, de la Rosa LR, Aliouat I, Guichard L, Pappa E, Le Guennec L, Nichelli L, Sangare A, Habert MO, Bayen E, Del Cul A, Mokhtari K, Cohen-Aubart F, Haroche J, Héritier S, Donadieu J, Hoang-Xuan K, Alentorn A, Idbaih A.   +18 more
europepmc   +2 more sources

International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults

Blood, 2022
Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary (smoking-associated), or multisystem disease.
G. Goyal, A. Tazi, R. Go, K. Rech, J. Picarsic, R. Vassallo, Jason R. Young, C. Cox, J. V. van Laar, M. Hermiston, Xin-xin Cao, P. Makras, G. Kaltsas, J. Haroche, M. Collin, K. McClain, E. Diamond, M. Girschikofsky   +17 more
semanticscholar   +1 more source

ALK+ histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.

Blood, 2021
ALK-related histiocytosis (formerly ALK-positive histiocytosis) is a rare subtype of histiocytic neoplasm first described in 2008 in three infants with multisystemic disease involving the liver and hematopoietic system.
P. Kemps, J. Picarsic, B. Durham, Z. Hélias‐Rodzewicz, L. Hiemcke-Jiwa, C. van den Bos, M. D. van de Wetering, C. V. van Noesel, J. V. van Laar, R. Verdijk, U. Flucke, P. Hogendoorn, F. J. S. H. Woei‐A‐Jin, R. Sciot, A. Beilken, F. Feuerhake, M. Ebinger, R. Möhle, F. Fend, A. Bornemann, V. Wiegering, K. Ernestus, T. Méry, O. Gryniewicz‐Kwiatkowska, B. Dembowska-Bagińska, D. Evseev, V. Potapenko, V. Baykov, S. Gaspari, S. Rossi, M. Gessi, G. Tamburrini, S. Héritier, J. Donadieu, Jacinthe Bonneau-Lagacherie, Claire Lamaison, L. Farnault, S. Fraitag, M. Jullie, J. Haroche, M. Collin, J. Allotey, Majid Madni, K. Turner, S. Picton, P. Barbaro, A. Poulin, Ingrid S Tam, D. El Demellawy, Brianna Empringham, J. Whitlock, A. Raghunathan, Amy A. Swanson, M. Suchi, Jon Brandt, N. Yaseen, J. Weinstein, I. Eldem, B. Sisk, V. Sridhar, Mandy M Atkinson, Lucas R. Massoth, J. Hornick, S. Alexandrescu, K. Yeo, K. Petrova-Drus, Stephen Z Peeke, Laura Muñoz-Arcos, D. Leino, D. Grier, R. Lorsbach, Somak Roy, Ashish R. Kumar, Shipra Garg, Nishant Tiwari, K. Schafernak, Michael M. Henry, A. V. van Halteren, O. Abla, E. Diamond, J. Emile   +80 more
semanticscholar   +1 more source

Langerhans cell histiocytosis in adults: literature review

Онкогематология, 2022
Langerhans cells histiocytosis is a variant of malignant histiocytosis. The course and symptoms vary. patients with localized forms have a better prognosis, because local therapy is effective.
V. G. Potapenko, V. V. Baykov, A. V. Zinchenko, N. A. Potikhonova   +3 more
doaj   +1 more source