Results 21 to 30 of about 10,494 (219)

Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis

Cell Communication and Signaling, 2022
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid malignancy in the “L-group” histiocytosis. Mitogen-activated protein kinase (MAPK) pathway activating mutations are detectable in nearly all LCH lesions. However, the pathogenic roles of MAPK
Xue-min Gao, Jian Li, Xin-xin Cao
doaj   +1 more source

Langerhans Cell Histiocytosis with Extensive Spinal and Thyroid Gland Involvement Presenting with Quadriparesis: An Unusual Case in an Adult Patient [PDF]

Malaysian Orthopaedic Journal, 2011
Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations.
Mohd Ariff S, Joehaimey J, Ahmad Sabri O, Zulmi W   +3 more
doaj   +1 more source

Neurodegenerative central nervous system disease as late sequelae of Langerhans cell histiocytosis. Report from the Japan LCH Study Group

Haematologica, 2008
Clinical features, brain magnetic resonance imaging findings and EDSS scores of 11 patients with neurodegenerative central nervous system Langerhans cell histiocytosis were analyzed in Japan.
Shinsaku Imashuku, Yoko Shioda, Ryoji Kobayashi, Gaku Hosoi, Hisanori Fujino, Shiro Seto, Hisashi Wakita, Akira Oka, Nagisa Okazaki, Naoto Fujita, Toshinori Minato, Kenichi Koike, Yukiko Tsunematsu, Akira Morimoto   +13 more
doaj   +1 more source

Pulmonary Langerhans cell histiocytosis causing spontaneous bilateral pneumothorax in a child

The Egyptian Journal of Internal Medicine, 2015
Bilateral pneumothorax is very rare in childhood. Moreover, if it is due to pulmonary involvement of Langerhans cell histiocytosis, it is even rarer in childhood.
Anupam Patra, Sujit K Bhattacharyay, Arnab Maji, Abhijit Mandal   +3 more
doaj   +1 more source

Langerhans Cell Histiocytosis of the Skull

Ear, Nose & Throat Journal, 2021
This is a case of a pediatric male who presented with a postauricular mass and pain. Computed tomography and magnetic resonance imaging suggested a diagnosis of Langerhans cell histiocytosis.
Adrian A. Ong MD, Mattie Rosi-Schumacher MD, Michael Pizzuto MD   +2 more
doaj   +1 more source

Langerhans' Cell Histiocytosis

Dermatology Online Journal, 2002
Adult onset Langerhans cell histiocytosis is uncommon. A 29 year old man is presented who developed classic cutaneous disease with severe systemic involvement. He responded completely to a two month course of thalidomide.
Mortazavi, Hessein, Ehsani, Amirhoushang, Namazi, Mohammad Reza, Hosseini, Mahbobeh   +3 more
openaire   +4 more sources

Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study

Journal of Clinical Oncology, 2019
PURPOSE Off-label use of vemurafenib (VMF) to treat BRAFV600E mutation–positive, refractory, childhood Langerhans cell histiocytosis (LCH) was evaluated. PATIENTS AND METHODS Fifty-four patients from 12 countries took VMF 20 mg/kg/d. They were classified
J. Donadieu, I. Larabi, M. Tardieu, J. Visser, C. Hutter, E. Sieni, N. Kabbara, M. Barkaoui, Jean Miron, F. Chalard, P. Milne, J. Haroche, F. Cohen, Z. Hélias-Rodzewicz, N. Simon, M. Jehanne, A. Kolenová, A. Pagnier, N. Aladjidi, P. Schneider, G. Plat, A. Lutun, Anne Sonntagbauer, T. Lehrnbecher, A. Ferster, V. Efremova, M. Ahlmann, Laurence Blanc, J. Nicholson, A. Lambilliote, H. Boudiaf, A. Lissat, K. Svojgr, Fanette Bernard, S. Elitzur, M. Golan, D. Evseev, M. Maschan, A. Idbaih, Olga Slater, M. Minkov, V. Taly, M. Collin, J. Alvarez, J. Emile, S. Héritier   +45 more
semanticscholar   +1 more source

Swelling of bilateral parotid glands: An unusual symptom of multisystem Langerhans cell histiocytosis

SAGE Open Medical Case Reports, 2014
Objective: Langerhans cell histiocytosis is an unusual disorder of unknown etiology with heterogeneous clinical behaviors and variable outcomes. It can involve one or more organs or systems, but to our best knowledge, parotid glands involvement in ...
Xiaojun Yuan, Mengjie Tang, Qi Sheng, Xiaodong Zhu, Qin Zhang   +4 more
doaj   +1 more source

Infantile and Adult Scabies mimicking Langerhans Cell Histiocytosis Clinically and Histopathologically

Journal of Contemporary Medicine, 2022
Scabies is an infestation caused by the Sarcoptes scabiei burrowing into the epidermis. Histopathologically scabies infestation may reveal Langerhans cell hyperplasia which might cause misdiagnosis of Langerhans cell histiocytosis in some cases.
Ayşe Esra Koku Aksu, Cem Leblebici, Duygu Erdil, Ecem Ergün, Dilara İlhan, Vildan Manav   +5 more
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Highlights of the Management of Adult Histiocytic Disorders: Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Rosai-Dorfman Disease, and Hemophagocytic Lymphohistiocytosis

Clinical Lymphoma, Myeloma & Leukemia, 2020
Histiocytic disorders are an exceptionally rare group of diseases with diverse manifestations and a paucity of approved treatments, thereby leading to various challenges in their diagnosis and management. With the discovery of novel molecular targets and
Hind Salama, A. Jazieh, A. Alhejazi, A. Absi, S. Alshieban, M. Alzahrani, A. Alaskar, G. Gmati, M. Damlaj, K. Abuelgasim, A. Alghamdi, B. Alahmari, Areej Almugairi, Hazzaa AlZahrani, A. Bazarbachi, Mohamed O Musa, G. Goyal   +16 more
semanticscholar   +1 more source