Results 31 to 40 of about 10,494 (219)
Rare Tumors, 2017 Langerhans cell sarcoma of the skin is a rare tumor with aggressive behavior. There are reports of Langerhans cell sarcoma involving the skin in patients with underlying systemic Langerhans cell histiocytosis.
Alejandro Peralta Soler +2 more
doaj +1 more source
Langerhans Cell Histiocytosis: An Unusual Presentation
Philippine Journal of Otolaryngology Head and Neck Surgery, 2008 Objective: To describe an unusual presentation of Langerhans cell histiocytosis in the craniofacial skeleton in a patient previously diagnosed with Pott’s disease. Methods: Design: Case report. Setting: Tertiary care center. Patient: One
Kathleen R. Fellizar +1 more
doaj +1 more source
JAMA Oncology, 2017 Importance The histiocytic neoplasms Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) are highly enriched for BRAF V600 mutations and have been previously shown to be responsive to treatment with vemurafenib, an inhibitor of the BRAF
E. Diamond +21 more
semanticscholar +1 more source
A Case of Multisystemic Langerhans Cell Histiocytosis in an Adult
Proceedings of Singapore Healthcare, 2011 Langerhans cell histiocytosis is a rare disease in adults with a myriad of clinical presentations. A case of multisystemic Langerhans cell histiocytosis with involvement of bone, skin, lungs, and the hypothalamic-pituitary-axis is reported.
Chiaw Ling Chng MBBS, MRCP
doaj +1 more source
Childhood Langerhans cell histiocytosis with severe lung involvement: a nationwide cohort study
Orphanet Journal of Rare Diseases, 2020 Background Lung involvement in childhood Langerhans cell histiocytosis (LCH) is infrequent and rarely life threatening, but occasionally, severe presentations are observed. Methods Among 1482 children (
Solenne Le Louet +25 more
doaj +1 more source
A Case of Orbital Langerhans Cell Histiocytosis in an Adult
Acta Médica Portuguesa, 2019 Langerhans cell histiocytosis remains an enigmatic disease with a very heterogeneous presentation. We describe a rare case of orbital Langerhans cell histiocytosis in a 39-year-old female patient who presented right orbital pain and edema of the upper ...
Inês Carneiro +2 more
doaj +1 more source
Journal of Indian Society of Periodontology, 2011 Langerhans cell histiocytosis (LCH) is a group of rare disorders histologically characterized by the proliferation of Langerhans cells. Multiple organs and systems may be involved by the disease. Typically, there is bone involvement and, less frequently, lesions may be found in the lungs, liver, lymph nodes, skin, and mucosa.
D R Aruna +3 more
openaire +3 more sources
BRAFV600E-induced senescence drives Langerhans Cell Histiocytosis pathophysiology
, 2020 Langerhans cell histiocytosis (LCH) is a potentially fatal condition characterized by granulomatous lesions with characteristic clonal mononuclear phagocytes (MNP) harboring activating somatic mutations in MAPK pathway genes, most notably BRAFV600E. We
M. Merad
semanticscholar +1 more source
Efficacy of BRAF-inhibitor therapy in BRAFV600E -mutated Adult Langerhans Cell Histiocytosis.
The Oncologist, 2020 Langerhans-cell histiocytosis (LCH) is a rare disease of unknown pathogenesis. To date, there is a lack of FDA-approved treatments in adult LCH to establish optimal first line therapy.
A. Hazim +15 more
semanticscholar +1 more source
Three cases of congenital self‐healing Langerhans cell histiocytosis with BRAF‐V600E mutation
JEADV Clinical Practice, 2022 Congenital self‐healing Langerhans cell histiocytosis (CSHLCH) is a rare variant of Langerhans cell histiocytosis characterised by the presence of skin lesions in the neonate and spontaneous self‐healing after a variable period of time.
Mar Ramírez‐Lluch +7 more
doaj +1 more source