Results 21 to 30 of about 56,324 (305)

Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO)

Pediatric Blood & Cancer, 2019
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation, often associated with genetic defects of lymphocyte cytotoxicity.
M. Jordan, C. Allen, Jay Greenberg, Michael M. Henry, M. Hermiston, Ashish R. Kumar, M. Hines, O. Eckstein, S. Ladisch, K. Nichols, C. Rodríguez-Galindo, B. Wistinghausen, K. McClain   +12 more
semanticscholar   +1 more source

Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study

Journal of Clinical Oncology, 2019
PURPOSE Off-label use of vemurafenib (VMF) to treat BRAFV600E mutation–positive, refractory, childhood Langerhans cell histiocytosis (LCH) was evaluated. PATIENTS AND METHODS Fifty-four patients from 12 countries took VMF 20 mg/kg/d. They were classified
J. Donadieu, I. Larabi, M. Tardieu, J. Visser, C. Hutter, E. Sieni, N. Kabbara, M. Barkaoui, Jean Miron, F. Chalard, Paul Milne, J. Haroche, F. Cohen, Z. Hélias‐Rodzewicz, N. Simon, M. Jehanne, A. Kolenová, A. Pagnier, N. Aladjidi, P. Schneider, G. Plat, A. Lutun, Anne Sonntagbauer, T. Lehrnbecher, A. Ferster, V. Efremova, M. Ahlmann, Laurence Blanc, J. Nicholson, A. Lambilliote, H. Boudiaf, A. Lissat, K. Svojgr, Fanette Bernard, S. Elitzur, M. Golan, D. Evseev, M. Maschan, A. Idbaih, Olga Slater, M. Minkov, V. Taly, M. Collin, J. Alvarez, J. Emile, S. Héritier   +45 more
semanticscholar   +1 more source

Langerhans cell histiocytosis on the penis: a case report

BMC Urology, 2006
Background Langerhans cell histiocytosis affects mainly young children and features an accumulation of CD1a+ dendritic Langerhans cells in the bone, skin, and other organs.
Kuroda Isao, Ashimine Satoshi, Ueno Munehisa, Hagiuda Jun, Ishizawa Keisuke, Deguchi Nobuhiro   +5 more
doaj   +1 more source

Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall [PDF]

, 2018
Benign TdT-positive cells have been documented in a variety of non-hematopoietic tissues. Scant data are however available on their presence in non-neoplastic lymph nodes.
AGOSTINELLI, CLAUDIO, Bertuzzi, Clara, BRIGNOLA, STEFANO, Pillon, Marta, Pizzi, Marco, Righi, Simona, Rugge, Massimo, Sabattini, Elena, Semenzato, Gianpietro   +8 more
core   +1 more source

Primary Langerhans Cell Histiocytosis of the Extrahepatic Bile Duct Occurring in an Adult Patient

Balkan Medical Journal, 2018
Background: Langerhans cell histiocytosis is characterized by an abnormal proliferation of neoplastic Langerhans cells. Langerhans cell histiocytosis commonly affects the pediatric population, whereas presentation in adults remains a rare event.
Ifeyinwa E. Obiorah, Alicia Henao Velasquez, Bhaskar Kallakury, Metin Özdemirli   +3 more
doaj   +1 more source

Adult Langerhans cell histiocytosis presenting with multisystem involvement and sarcomatoid features: a case report

Journal of Medical Case Reports, 2020
Background Langerhans cell tumors are rare clonal disorders characterized by neoplastic proliferation of dendritic cells that can be further classified into the subtypes Langerhans cell histiocytosis and Langerhans cell sarcoma, which are rare neoplasms ...
Luis E. Aguirre, Ingrid Schwartz, Jennifer Chapman, Marcelo F. Larsen, Alvaro Alencar   +4 more
doaj   +1 more source

BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease. [PDF]

, 2014
Erdheim-Chester disease (ECD) is a rare histiocytosis with a high prevalence of BRAF V600E mutation (>50% of patients). Patients with BRAF-mutant ECD can respond to BRAF inhibitors.
Cabrilo, Goran, Erlander, Mark G, Hassaine, Latifa, Holley, Veronica R, Janku, Filip, Kosco, Karena, Kurzrock, Razelle, Leppin, Lorieta, Lin, Patrick P, Meric-Bernstam, Funda, Poole, Jason C, Stepanek, Vanda M, Vibat, Cecile Rose T   +12 more
core   +3 more sources

Neurodegenerative central nervous system disease as late sequelae of Langerhans cell histiocytosis. Report from the Japan LCH Study Group

Haematologica, 2008
Clinical features, brain magnetic resonance imaging findings and EDSS scores of 11 patients with neurodegenerative central nervous system Langerhans cell histiocytosis were analyzed in Japan.
Shinsaku Imashuku, Yoko Shioda, Ryoji Kobayashi, Gaku Hosoi, Hisanori Fujino, Shiro Seto, Hisashi Wakita, Akira Oka, Nagisa Okazaki, Naoto Fujita, Toshinori Minato, Kenichi Koike, Yukiko Tsunematsu, Akira Morimoto   +13 more
doaj   +1 more source

Cytophagic Histiocytic Panniculitis (CHP) in a Patient with SLE Found after Autopsy: When a Rash Is "Complicated!" [PDF]

, 2019
Introduction: Cytophagic histolytic panniculitis (CHP) is a clinical disorder characterized by nodular panniculitis of the subcutaneous adipose tissue. It was first described in 1980 by Winkelmann.
Abbas, Hafsa, Aslam, Ahsan, Chilimuri, Sridhar, Niazi, Masooma, Saad, Muhammad   +4 more
core   +1 more source

Intermediate-dose cytarabine is an effective therapy for adults with non-Langerhans cell histiocytosis

Orphanet Journal of Rare Diseases, 2022
Background Non-Langerhans cell histiocytosis, including Erdheim–Chester disease (ECD), Rosai–Dorfman disease (RDD), indeterminate cell histiocytosis (ICH), and unclassified histiocytosis, is a rare disorder lacking a standard treatment strategy.
Ting Liu, Hua-cong Cai, Hao Cai, Miao Chen, Wei Zhang, Jian Li, Dao-bin Zhou, Xin-xin Cao   +7 more
doaj   +1 more source