Results 1 to 10 of about 7,562 (127)

Pulmonary Langerhans Cell Histiocytosis Presenting as Multiple Obstructing Bronchial Lesions and Pulmonary Masses. [PDF]

Clin Respir J
We describe a case of PLCH presenting as multiple obstructing bronchial lesions and pulmonary masses in a 36‐year‐old man. To our knowledge, this is the first report of PLCH presenting as bilateral hilar masses and airway obstructive lesions. ABSTRACT Pulmonary Langerhans cell histiocytosis is a rare lung disease, which was previously classified as ...
Fan J, Liu C, Yang Z, Sun D.
europepmc   +2 more sources

Langerhans Cell Histiocytosis Associated With Chronic Myeloid Leukemia: A Pediatric Case Report. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Langerhans cell histiocytosis (LCH) is a rare clonal neoplasm driven by activating mutations in the MAPK pathway, leading to accumulation of pathological Langerhans cells in various tissues. LCH is increasingly associated with secondary malignancies, including leukemias, lymphomas, and solid tumors. However, chronic myeloid leukemia
Latifi A, Yousefian S.
europepmc   +2 more sources

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real-world study. [PDF]

Int J Cancer
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Tang X, Sun JJ, Wan Z, Jing XY, Guo X, Gao J.   +5 more
europepmc   +2 more sources

Clinicopathological Features, Treatment Response, and Outcome of Rosai‐Dorfman Disease in Two Children [PDF]

Clin Case Rep
ABSTRACT Rosai‐Dorfman disease is a rare non‐Langerhans cell histiocytic disorder. It is common in male children and young adults of African descent. It is classified into sporadic and familial types. The most common clinical presentation is massive bilateral cervical lymphadenopathy associated with constitutional symptoms. Histiocytic emperipolesis is
Evele G, Francine K.
europepmc   +2 more sources

Langerhans cell histiocytosis (histiocytosis X) [PDF]

Postgraduate Medical Journal, 1997
Summary There has been a renewed interest in Langerhans cell histiocytosis in recent years due both to advances in basic research and to improvements in diagnostic and treatment approaches. In this article, we review the various aspects of the disease and the potential implications of these recent scientific researches for our ...
openaire   +3 more sources

Ventilation Imaging of the Lung at 0.55T With Continuous Slice Cycling

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To propose and evaluate a novel method for pulmonary ventilation imaging, offering considerably improved SNR. Methods A continuous slice cycling (CSC) acquisition scheme is proposed to exclusively capture signal modulations from respiratory motion with increased SNR.
Andrea Leuthard, Grzegorz Bauman, Katrin E. Hostettler, Maurice Pradella, Oliver Bieri   +4 more
wiley   +1 more source

Next‐Generation Paleopathology: Using Commercial AI in Bioarchaeological Diagnosis

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics.
Jessica Mongillo, Giulia Vescovo, Giulia Manzo, Nicoletta Zedda, Barbara Bramanti   +4 more
wiley   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Pulmonary Histiocytosis X

Annals of Saudi Medicine, 1998
g twice a day.In November 1994 she was re-admitted to a secondhospital with a right-sided pneumothorax. In addition tothe pneumothorax, the chest x-ray showed diffuseinterstitial infiltration of both lungs, with normal lungvolumes. Computed tomography (CT) of the chest showeddiffuse interstitial disease, with multiple thin and thick-walled cysts of ...
H, Al-Jahdali, A, Al-Shimemeri, H, Bamefleh, M, Al-Moamary   +3 more
openaire   +2 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source