Results 21 to 30 of about 5,875,026 (205)

Histiocytosis development and clinical variation through the lens of genomics. [PDF]

J Pathol
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Kemps PG, van Halteren AG, van Wezel T, Hogendoorn PC.   +3 more
europepmc   +2 more sources

MEK inhibition achieves robust and durable responses in Erdheim–Chester disease [PDF]

Hemasphere
Abstract Erdheim–Chester disease (ECD) is a rare histiocytic neoplasm characterized by heterogeneous clinical manifestations and limited evidence to guide targeted therapy. While MEK inhibitors (MEKi) are increasingly used, data on their real‐world efficacy, durability, and safety remain incomplete.
Pegoraro F, Triboulet F, Papo M, Peyronel F, Argentieri A, Razanamahery J, Idbaih A, Makras P, Shpilberg O, Hershkovitz‐Rokah O, Girschikofsky M, Collin M, Bowles K, Gohil S, Amerikanou R, Ledoult E, Le Scornet T, de Menthon M, Riviere E, Boulu X, Dupuy H, Aouba A, Faguer S, Solanich X, Sieni E, Barete S, Bellino C, Tomelleri A, Campochiaro C, Dagna L, Amoura Z, Emile J, Cohen‐Aubart F, Vaglio A, Haroche J.   +34 more
europepmc   +2 more sources

Vulvar Langerhans cell histiocytosis: a case report

The Pan African Medical Journal, 2014
Langerhans cell histiocytoses (LCH) are a rare group of disorders that comprise a large spectrum of diseases initially known as histiocytosis X. In this case report, we relate a case of LCH affecting the vulva of a 47-year-old female.
Nadia Khoummane, Cyriane Guimeya, Dominique Lipombi, Franeois Gielen   +3 more
doaj   +1 more source

Langerhans cell histiocytosis in an adult with oral cavity involvement: Posing a diagnostic challenge

Contemporary Clinical Dentistry, 2019
Langerhans cell histiocytosis (LCH) is a rare hematological disorder characterized by local or generalized, uncontrolled proliferation and infiltration of Langerhans type of histiocytic cells.
Richa Nangalia, Rudra Prasad Chatterjee, Sanchita Kundu, Mousumi Pal   +3 more
doaj   +1 more source

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom. [PDF]

Br J Haematol
Trametinib (MEK inhibitor) shows efficacy in refractory and high‐risk adult histiocytic neoplasms. At a median follow‐up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).
Amerikanou R, Munir T, Bowles K, McNamara C, Chavda N, Price E, Adiyodi J, Coles A, Kelsey P, Smith J, Adams R, Hussein H, Zhao R, Nguyen T, Collin M, Gohil S.   +15 more
europepmc   +2 more sources

Giant Cell Lesion or Langerhans' Cell Histiocytosis of the Mandible? A Case Report

European Journal of Inflammation, 2012
Langerhans' cell histiocytosis (LCH), formerly known as histiocytosis X, is characterized by cell proliferation. The leading clinical symptom of LCH within mandibular and maxillary bones is pain and it may resemble periodontal diseases, apical cysts ...
V. Valentini, V. Terenzi, A. Cassoni, S. Bosco, E. Brauner, J. Shahinas, G. Pompa   +6 more
doaj   +1 more source

Langerhans cell histiocytosis with presentation as orbital disease

Journal of Pediatric Neurosciences, 2015
Langerhans cell histiocytosis (LCH) is an uncommon multisystem disease with an abnormal polyclonal proliferation of Langerhans cells that invade various organs. In rare instances, the affection of the orbit is the only and the first symptom. We report an
Ashok B Bhanage, Anand D Katkar, Prajakta S Ghate   +2 more
doaj   +1 more source

Langerhans cell histiocytosis: A case report with oral manifestations and the role of pediatric dentists in the diagnosis

Clinical Case Reports, 2020
Langerhans cell histiocytosis (LCH) is a benign disease that behaves malignantly. Early recognition and treatment of oral manifestation of LCH by pediatric dentist and other medical specialties is important to prevent further organ damage.
Eman Hussein Hammouri, Hala Antoun Sweidan, Omar AShokaibi, Leen Al Omari   +3 more
doaj   +1 more source

Disseminated Langerhans Cell Histiocytosis Presenting as Cholestatic Jaundice [PDF]

Journal of Clinical and Diagnostic Research, 2015
Langerhans cell histiocytosis (LCH) is a disorder associated with proliferation of Langerhans cells in various organs. LCH secondary to multisystem involvement can present in a variety of ways.
Rohit Kapoor, Anthony M. Loizides, Soumya Sachdeva, Premila Paul   +3 more
doaj   +1 more source

A nationwide multicenter observational study on childhood scurvy in Japan

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Although scurvy is rare in developed countries, cases in children with selective diets due to neurodevelopmental disorders have been increasingly reported in Japan. In this nationwide multicenter observational study, we aimed to clarify the clinical characteristics and diagnostic challenges faced by children with scurvy in Japan ...
Yu Masuda, Ryohei Fukatsu, Ryosuke Miyamoto, Hitoshi Honma, Yoshinori Ito, Hiromichi Shoji, Masanobu Kawai, Yuri Etani, Toshiaki Shimizu, Akihisa Okumura   +9 more
wiley   +1 more source