Results 101 to 110 of about 197,788 (257)

Major histocompatibility complex class I during pregnancy and at parturition in the horse placenta

, 2018
Major histocompatibility complex class I during pregnancy and at parturition in the horse ...
Tomasz Janowski (554246), Małgorzata Chmielewska-Krzesińska (7007681), Anna Rapacz-Leonard (7007678), Mark Leonard (4674868), Katarzyna Paździor-Czapula (7007684)   +4 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Current status and perspectives of the quality system in histocompatibility laboratories in Poland

Frontiers in Genetics
Allogeneic transplantation is a multi-step process involving many clinicians and laboratory personnel working together to achieve a common goal—to maximize the recipients’ chance of survival and to improve their quality of life.
Izabela Uhrynowska-Tyszkiewicz, Izabela Uhrynowska-Tyszkiewicz, Katarzyna Bogunia-Kubik, Monika Baj-Krzyworzeka, Monika Baj-Krzyworzeka, Barbara Piątosa, Barbara Piątosa   +6 more
doaj   +1 more source

The genomic anchors of the human major histocompatibility complex [PDF]

, 2009
Eukaryotic chromatin is organised into a hierarchy of topologically constrained loop structures. Matrix Attachment Regions (MARs) are genomic sequences that mediate the anchoring of chromatin to the insoluble proteinaceous fraction of the nucleus known
Ottaviani, D., Ottaviani, D
core  

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Histocompatibility Testing for Organ Transplantation Purposes in Albania: A Single Center Experience

Balkan Medical Journal, 2014
Background: Histocompatibility testing (HT) which includes donor-recipient human leukocyte antigen (HLA) matching, cross-match testing (XMT) and anti-HLA antibody searching are crucial examinations in solid organ transplantation aiming to avoid the ...
Erkena Shyti, Genc Sulcebe, Alma Idrizi
doaj   +1 more source

Major histocompatibility complex heterozygote superiority during coinfection [PDF]

, 2003
journal articleGenes of the major histocompatibility complex (MHC) play a critical role in immune recognition, and many alleles confer susceptibility to infectious and autoimmune diseases.
McClelland, Erin E.; Penn, Dustin J., Potts, Wayne K.   +1 more
core  

A DNA vaccine construct incorporating intercellular trafficking and intracellular targeting motifs effectively primes and induces memory B and T cell responses in outbred animals [PDF]

, 2007
We developed a vaccine construct in which a BVP22 domain and an invariant-chain major histocompatibility complex class II-targeting motif capable of enhancing dendritic cell antigen uptake and presentation were fused to a sequence encoding a B- and T ...
Palmer, Guy H, Zhuang, Yan, Mwangi, W, Howard, CJ, Aida, Yoko, Hunter, Beverly J, Splitter, Gary A, Brown, WC, Palmer, GH, Hunter, BJ, Aida, Y, Davies, Christopher J, Brown, Wendy C, Davies, CJ, Mwangi, Waithaka, Splitter, GA, Zhuang, Y, Hope, Jayne; id_orcid, Howard, Chris J, Hope, Jayne C   +19 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Evaluation of 19 years of international external proficiency testing for high-resolution HLA typing

Frontiers in Genetics
The international high-resolution external proficiency testing (EPT) started in 2004 with high-resolution typing of human leucocyte antigen (HLA) class I (HLA-A,B,C) and HLA class II (HLA-DRB1, DRB345, DQB1, and DPB1) alleles, since possibilities for ...
C. E. M. Voorter, L. Groeneveld, S. Heidt, S. Heidt, L. Wieten   +4 more
doaj   +1 more source