Results 1 to 10 of about 150,558 (258)

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase [PDF]

Frontiers in Immunology, 2020
Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs.
Anita N. Kremer, Judith Bausenwein, Ellie Lurvink, Andreas E. Kremer, Caroline E. Rutten, Cornelis A. M. van Bergen, Sascha Kretschmann, Edith van der Meijden, Maria W. Honders, Daniela Mazzeo, Colin Watts, Andreas Mackensen, J. H. Frederik Falkenburg, Marieke Griffioen   +13 more
doaj   +4 more sources

Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens [PDF]

Frontiers in Immunology, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
Kyra J. Fuchs, M. Willy Honders, Edith D. van der Meijden, Edith D. van der Meijden, Alwin E. Adriaans, Dyantha I. van der Lee, Margot J. Pont, Margot J. Pont, Ramin Monajemi, Szymon M. Kielbasa, Peter A. C. ’t Hoen, Peter A. C. ’t Hoen, Cornelis A. M. van Bergen, J. H. Frederik Falkenburg, Marieke Griffioen   +14 more
doaj   +2 more sources

TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens [PDF]

Frontiers in Immunology, 2020
Minor histocompatibility antigens (mHAgs) in allogeneic hematopoietic stem cell transplantation are highly immunogenic as they are foreign antigens and cause polymorphism between donors and recipients. Adoptive cell therapy with mHAg-specific T cells may
Yoshiki Akatsuka
doaj   +2 more sources

Identification of minor histocompatibility antigens based on the 1000 Genomes Project [PDF]

Haematologica, 2014
Minor histocompatibility antigens are highly immunogeneic polymorphic peptides playing crucial roles in the clinical outcome of HLA-identical allogeneic stem cell transplantation.
Rimke Oostvogels, Henk M. Lokhorst, Monique C. Minnema, Maureen van Elk, Kelly van den Oudenalder, Eric Spierings, Tuna Mutis, Robbert M. Spaapen   +7 more
doaj   +2 more sources

A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation [PDF]

Frontiers in Immunology, 2021
Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause immune responses involved in graft-versus-host disease (GVHD) and graft-versus-leukemia effects after allogeneic hematopoietic cell transplantation (HCT ...
Paul J. Martin, Paul J. Martin, David M. Levine, Barry E. Storer, Xiuwen Zheng, Deepti Jain, Ben Heavner, Brandon M. Norris, Daniel E. Geraghty, Stephen R. Spellman, Cassie L. Sather, Feinan Wu, John A. Hansen, John A. Hansen   +13 more
doaj   +2 more sources

In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]

Frontiers in Immunology 2014. 5:529, 2014
Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
Batalo, Michael, Buck, Gregory A., Griffith, Phil, Hess, Michael L., Jameson-Lee, Max, Khalid, Haniya, Koparde, Vishal, Manjili, Masoud H., Neale, Michael C., Roberts, Catherine H., Sampson, Juliana K., Scalora, Allison F., Serrano, Myrna G., Sheth, Nihar U., Toor, Amir A.   +14 more
arxiv   +5 more sources

Minor histocompatibility antigens HA‐8 and PANE1 in the TUNISIAN population [PDF]

Molecular Genetics & Genomic Medicine, 2022
Background Minor histocompatibility antigens (mHAgs) are endogenous immunogenic peptides initially identified due to complications detected in several contexts of HLA geno‐identical hematopoietic stem cell transplantation (HSCT).
Rahma Said, Mohamed Hichem Sellami, Houda Kaabi, Slama Hmida   +3 more
doaj   +2 more sources

Rapid Multiplex Genotyping of 20 HLA-A*02:01 Restricted Minor Histocompatibility Antigens [PDF]

Frontiers in Immunology, 2019
A subset of MHC-associated self-peptides presented by the recipient's cells and immunologically foreign to the donor can induce an allogeneic immune response after hematopoietic stem cell transplantation (HSCT).
Dmitrii S. Romaniuk, Anna M. Postovskaya, Alexandra A. Khmelevskaya, Dmitry B. Malko, Grigory A. Efimov   +4 more
doaj   +2 more sources

Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens [PDF]

Blood Advances, 2018
: T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant.
Jefferson L. Lansford, Udara Dharmasiri, Shengjie Chai, Sally A. Hunsucker, Dante S. Bortone, James E. Keating, Ian M. Schlup, Gary L. Glish, Edward J. Collins, Gheath Alatrash, Jeffrey J. Molldrem, Paul M. Armistead, Benjamin G. Vincent   +12 more
doaj   +2 more sources

Autosomal minor histocompatibility antigens; How genetic variants create diversity in immune targets [PDF]

Frontiers in Immunology, 2016
Allogeneic hematopoietic stem cell transplantation (alloSCT) can be a curative treatment for hematological malignancies. Unfortunately, the desired anti-tumor or Graft-versus-Leukemia (GvL) effect is often accompanied with undesired side effects against ...
Marieke eGriffioen, Cornelis A.M. van Bergen, J.H.Frederik eFalkenburg   +2 more
doaj   +2 more sources