Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens [PDF]
Frontiers in Immunology, 2020 Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
Kyra J. Fuchs +14 more
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TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens [PDF]
Frontiers in Immunology, 2020 Minor histocompatibility antigens (mHAgs) in allogeneic hematopoietic stem cell transplantation are highly immunogenic as they are foreign antigens and cause polymorphism between donors and recipients. Adoptive cell therapy with mHAg-specific T cells may
Yoshiki Akatsuka
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Identification of minor histocompatibility antigens based on the 1000 Genomes Project [PDF]
Haematologica, 2014 Minor histocompatibility antigens are highly immunogeneic polymorphic peptides playing crucial roles in the clinical outcome of HLA-identical allogeneic stem cell transplantation.
Rimke Oostvogels +7 more
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A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation [PDF]
Frontiers in Immunology, 2021 Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause immune responses involved in graft-versus-host disease (GVHD) and graft-versus-leukemia effects after allogeneic hematopoietic cell transplantation (HCT ...
Paul J. Martin +13 more
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Minor histocompatibility antigens HA‐8 and PANE1 in the TUNISIAN population [PDF]
Molecular Genetics & Genomic Medicine, 2022 Background Minor histocompatibility antigens (mHAgs) are endogenous immunogenic peptides initially identified due to complications detected in several contexts of HLA geno‐identical hematopoietic stem cell transplantation (HSCT).
Rahma Said +3 more
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Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens [PDF]
Blood Advances, 2018 : T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant.
Jefferson L. Lansford +12 more
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Rapid Multiplex Genotyping of 20 HLA-A*02:01 Restricted Minor Histocompatibility Antigens [PDF]
Frontiers in Immunology, 2019 A subset of MHC-associated self-peptides presented by the recipient's cells and immunologically foreign to the donor can induce an allogeneic immune response after hematopoietic stem cell transplantation (HSCT).
Dmitrii S. Romaniuk +4 more
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Single step multiple genotyping by MALDI-TOF mass spectrometry, for evaluation of minor histocompatibility antigens in patients submitted to allogeneic stem cell transplantation from HLA-matched related and unrelated donor [PDF]
Hematology Reports, 2017 The outcome of patients underwent to allogeneic stem cell transplantation (allo- SCT) is closely related to graft versus host disease (GvHD) and graft versus leukemia (GvL) effects which can be mediated by mHAgs.
Federica Cattina +9 more
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Assembly of histocompatibility antigens [PDF]
Methods in enzymology, 1983 Dobberstein, Bernhard, Kvist, Sune
core +4 more sources
T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies
Frontiers in Immunology, 2020 Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell transplantation, most of the so-called graft-vs.-leukemia (GVL) effect hinges on the recognition of ...
Valérie Janelle +6 more
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