Results 111 to 120 of about 150,657 (357)
Helper T cells for cytotoxic T lymphocytes need not be I region restricted. [PDF]
, 1982 We investigated the antigenic requirements for restimulation of H-2- restricted cytolytic T lymphocytes (CTL) in vitro to determine whether H-2 I region-restricted helper T cells are required in these responses.
Bevan, M, RAULET, David H.
core +1 more source
Advanced Science, EarlyView.The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao +13 more
wiley +1 more source
Dynamics-based peptide-MHC binding optimization by a convolutional variational autoencoder: a use-case model for CASTELO [PDF]
arXiv, 2020 An unsolved challenge in the development of antigen specific immunotherapies is determining the optimal antigens to target. Comprehension of antigen-MHC binding is paramount towards achieving this goal. Here, we present CASTELO, a combined machine learning-molecular dynamics (ML-MD) approach to design novel antigens of increased MHC binding affinity ...
arxiv
Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. [PDF]
, 1985 Autoimmune NZB/NZW mice were treated with weekly injections of monoclonal antibody (mAb) to L3T4, an antigen expressed on a distinct subpopulation of T cells that respond to class II major histocompatibility antigens.
Seaman, WE, Wofsy, D
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Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC
Advanced Science, EarlyView.AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao +15 more
wiley +1 more source
Journal of Immunology Research, 2017 Chronic diseases that result in end-stage organ damage cause inflammation, which can reveal sequestered self-antigens (SAgs) in that organ and trigger autoimmunity. The thymus gland deletes self-reactive T-cells against ubiquitously expressed SAgs, while
Ankit Bharat, T. Mohanakumar
doaj +1 more source
ROLE OF HLA IN RENAL TRANSPLANT REJECTION
Alʹmanah Kliničeskoj Mediciny, 2016 It is known that the number of matches of the major histocompatibility complex antigens has a direct relationship with the duration of a renal transplant functioning.
A. V. Vatazin +4 more
doaj +1 more source
Antibody Responses to Minor Histocompatibility Antigens After Solid Organ Transplantation. [PDF]
Transplantation, 2022 Zorn E, See SB.
europepmc +1 more source
Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail [PDF]
, 1986 Truncated variants of the gene encoding H-2Ld, an integral membrane protein encoded by the major histocompatibility complex, were constructed by in vitro mutagenesis to elucidate the function of charged amino acids found on the cytoplasmic side of the ...
Hood, Leroy E., Zuñiga, Martha C.
core