Results 271 to 280 of about 150,657 (357)

Feedback regulation of VISTA and Treg by TNF‐α controls T cell responses in drug allergy

Allergy, EarlyView.
TNF‐α breaks immune tolerance by regulating the VISTA at early stage of the drug‐specific T‐cell response. The response of drug‐responsive effector T cells was negative feedback regulated by increasing Treg cells. This indicates that Treg agonists, rather than TNF‐α antagonists, could be used to treat patients with progressive SCARs.
Lele Sun, Qing Zhao, Suiting Ao, Tingting Liu, Zhenzhen Wang, Jiabao You, Zihao Mi, Yonghu Sun, Xiaotong Xue, Monday O. Ogese, Joshua Gardner, Xiaoli Meng, Dean J. Naisbitt, Hong Liu, Furen Zhang   +14 more
wiley   +1 more source

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy

Allergy, EarlyView.
We used patient samples and a murine model to understand the contribution of Bregs to EoE immunopathology. We find that Breg‐derived IL‐10 is important for controlling EoE, but that Breg expansion and function are impaired in this condition. We identify IFNγ as a key negative regulator of Breg function in mice and patients with EoE. Bregs, regulatory B
Rachel L. Clement, Julie Dilollo, Eric M. Rodríguez‐López, Cleandre M. Guerrier, David A. Hill   +4 more
wiley   +1 more source

Ribosome profiling shows variable sensitivity to detect open reading frames for conventional and different types of cryptic T cell antigens. [PDF]

Mol Ther Methods Clin Dev
Fuchs KJ, Thomaidou S, van der Slik AR, van de Meent M, 't Hoen PAC, Falkenburg JHF, Zaldumbide A, Griffioen M.   +7 more
europepmc   +1 more source

Characterization of a porcine genomic clone encoding a major histocompatibility antigen: expression in mouse L cells.

, 1982
Dinah S. Singer, R. Daniel Camerini‐Otero, M. Leonardo Satz, Barbara A. Osborne, David H. Sachs, Stuart Rudikoff   +5 more
openalex   +1 more source

Review Article: Novel Enzyme Therapy Design for Gluten Peptide Digestion Through Exopeptidase Supplementation

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 7, Page 1123-1139, April 2025.
Exopeptidases are key for completing protein digestion, including proline‐rich peptides, and are mostly produced by enterocytes of the intestinal brush border membrane. In coeliac disease, chronic inflammation leads to reduced brush border exopeptidase activity, exacerbating peptide accumulation.
Erin R. Bonner, Werner Tschollar, Robert Anderson, Sulayman Mourabit   +3 more
wiley   +1 more source

Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy. [PDF]

J Immunother Cancer
Van der Vreken A, Thery F, Tu C, Mwangi K, Meulewaeter S, De Beck L, Janssens E, De Veirman K, Vanderkerken K, De Bruyne E, Franceschini L, Impens F, Verbeke R, Lentacker I, Menu E, Breckpot K.   +15 more
europepmc   +1 more source

Origins of T‐cell‐mediated autoimmunity in acquired aplastic anaemia

British Journal of Haematology, Volume 206, Issue 4, Page 1035-1053, April 2025.
Acquired aplastic anaemia (AA) is an autoimmune bone marrow failure disease caused by a cytotoxic T‐cell–mediated attack on haematopoietic stem and progenitor cells (HSPCs). Despite significant progress in understanding T‐cell repertoire alterations in AA, the identification of specific pathogenic T cells remains elusive.
Aura Enache, Shannon A. Carty, Daria V. Babushok   +2 more
wiley   +1 more source

Antigen presentation of post-translationally modified peptides in major histocompatibility complexes. [PDF]

Immunol Cell Biol
de Wit AS, Bianchi F, van den Bogaart G.
europepmc   +1 more source

DONOR CLASS I AND CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION FOLLOWING LIVER ALLOGRAFTING IN REJECTING AND NONREJECTING RAT STRAIN COMBINATIONS

, 1988
Abdellatif Settaf, A.D. Milton, Sarah C. Spencer, D Houssin, John W. Fabre   +4 more
openalex   +1 more source

Indirect presentation of mismatched human leukocyte antigen‐B associates with outcomes of cord blood transplantation

British Journal of Haematology, Volume 206, Issue 5, Page 1406-1417, May 2025.
This study analysed 1498 single‐unit cord blood transplantation (CBT) cases (2000–2018) to evaluate the impact of mismatched human leukocyte antigen (HLA) immunogenicity. Results highlighted that Class I epitopes from recipient‐mismatched HLA‐B were associated with higher transplantation‐related mortality (TRM) and lower neutrophil engraftment ...
Takeshi Sugio, Kohta Miyawaki, Naoyuki Uchida, Matthias Niemann, Eric Spierings, Kyohei Mori, Yuju Ohno, Tetsuya Eto, Yasuo Mori, Goichi Yoshimoto, Yoshikane Kikushige, Yuya Kunisaki, Shinichi Mizuno, Koji Nagafuji, Hiromi Iwasaki, Tomohiko Kamimura, Ryosuke Ogawa, Toshihiro Miyamoto, Shuichi Taniguchi, Koichi Akashi, Koji Kato   +20 more
wiley   +1 more source