Results 291 to 300 of about 150,657 (357)

The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship. [PDF]

Front Nutr
Zúñiga VA, Bazan-Perkins B.
europepmc   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Allorecognition Unveiled: Integrating Recent Breakthroughs Into the Current Paradigm. [PDF]

Transpl Int
Charmetant X, Pettigrew GJ, Thaunat O.
europepmc   +1 more source

The impact of BTK knockdown on lung adenocarcinoma growth and immune response

Cancer Science, EarlyView.
First study on BTK's role in LUAD progression. Low BTK expression associated with poor LUAD prognosis. Abstract This study explores the molecular role of the BTK gene in lung adenocarcinoma (LUAD) progression and patient prognosis. Using a radiomics model based on BTK expression and PET‐CT data analyzed through DeeplabV3, alongside transcriptomic and ...
Jilan Huang, Yufan Yuan, Linghong Guo, Guojin Xia, Yan Chen, Qi Chen, Min Wang   +6 more
wiley   +1 more source

CAR-T cell therapy based on a TCR mimic nanobody targeting an intracellular antigen for solid cancers. [PDF]

Mol Ther Oncol
Lin Q, Jin S, Wang M.
europepmc   +1 more source

Sero-typing of human lymphocyte antigens: Preliminary trials on long-term kidney homograft survivors [PDF]

, 1965
Marchioro, TL, Starzl, TE, Terasaki, PI
core  

High Antigenicity for Treg Cells Confers Resistance to PD‐1 Blockade Therapy via High PD‐1 Expression in Treg Cells

Cancer Science, Volume 116, Issue 5, Page 1214-1226, May 2025.
High antigenicity of Treg cells confers resistance to anti‐PD‐1 mAb monotherapy via high PD‐1 expression in Treg cells. Resistance to anti‐PD‐1 mAb monotherapy via high PD‐1 expression in Treg cells can be overcome by combination therapy with an anti‐CTLA‐4 mAb.
Hiroaki Matsuura, Takamasa Ishino, Toshifumi Ninomiya, Kiichiro Ninomiya, Kota Tachibana, Akiko Honobe‐Tabuchi, Yoshinori Muto, Takashi Inozume, Youki Ueda, Kadoaki Ohashi, Yoshinobu Maeda, Joji Nagasaki, Yosuke Togashi   +12 more
wiley   +1 more source

Irreversible electroporation synergizes with oncolytic virus enhances the infiltration of cytotoxic T lymphocytes in the tumor immune microenvironment: a leap from focal therapy to immunotherapy for prostate cancer. [PDF]

J Immunother Cancer
Xia ZY, Xiang JC, Xu JZ, Sun JX, Wang S, Xia QD.   +5 more
europepmc   +1 more source

Differentiation of Cytotoxic CD8+ T Cell Subsets Under Tumor Progression: Can CD69 Be a New Therapeutic Target?

Cancer Science, EarlyView.
This review summarizes the current understanding of cytotoxic CD8+ T cell subset differentiation under tumor progression and highlights the crucial role of chronic CD8+ T cell responses in anti‐tumor immunity. CD69 is an important regulator of chronic CD8+ T cell response that contributes to the induction of the Tox gene via calcineurin/NFAT signaling.
Ryo Koyama‐Nasu, Yangsong Wang, Hinata Miyano, Motoko Y. Kimura   +3 more
wiley   +1 more source

In Vitro Expansion and Transduction of Primary NK Cells Using Feeder Cells Expressing Costimulatory Molecules and IL‐21

Cancer Science, EarlyView.
Our findings show that feeder cells expressing CD80, 41BBL and membrane‐bound IL‐21 promote optimal NK cell expansion. We also evaluated CAR transduction efficiency into expanded NK cells using different lentiviral vectors. The results indicate that NK cells transduced with the BaeV lentivirus exhibit high cytotoxicity toward target cells.
Thi Bao Tram Tran, Thi Van Anh Bui, Thi Minh Thu Tran, Nguyen Minh Nguyen, Hoang Thien Phuc Nguyen, Thi Phuong Diem Tran, Duc Minh Quan Nguyen, Thai Minh Quan Ngo, Thanh Binh Nguyen, Els Verhoeyen, Nhat Thang Tran, Hoai‐Nghia Nguyen, Le Son Tran   +12 more
wiley   +1 more source