Results 171 to 180 of about 60,221 (291)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Differential Alloreactivity: Lessons Learned From a Singular HLA Locus. [PDF]

HLA
Arrieta-Bolaños E.
europepmc   +1 more source

Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity

, 1997
Todd D. Armstrong, Virginia K. Clements, Brian K. Martin, Jenny P.‐Y. Ting, Suzanne Ostrand‐Rosenberg   +4 more
openalex   +2 more sources

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Molecular Mechanism for the Selective Presentation of Antigenic Peptides by Major Histocompatibility Complex Class I and Class II Molecules: A Hypothesis. [PDF]

Curr Issues Mol Biol
Zhu BT.
europepmc   +1 more source

Molecular dissection of the antigen binding site of a major histocompatibility complex class II molecule and stochastic modelling of macromolecular interactions in the living cell

, 1991
Jean Peccoud
openalex   +1 more source

Prognostic significance of major histocompatibility complex class II antigens (HLA-DR) in normal colonic mucosa, tubulovillous adenoma, and invasive colonic carcinoma

, 2006
Demetrio Tamiolakis, Sylvia Nicolaidou, S. Bolioti, Anna Tzilivaki   +3 more
openalex   +1 more source

HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain [PDF]

, 2020
openaire   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

The IPD-IMGT/HLA database: recent developments in sequence submission. [PDF]

Nucleic Acids Res
Barker DJ, Natarajan RHL, Cooper MA, Hopper SJF, Yates AD, Parham P, Marsh SGE, Robinson J.   +7 more
europepmc   +1 more source