Results 71 to 80 of about 13,369,567 (232)
International Journal of Nanomedicine, 2021 Jiaojiao Cao,1,* Jie Huang,1,* Shuangying Gui,1,2 Xiaoqin Chu1,2 1Department of Pharmaceutics, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic of China; 2Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei ...
Cao J, Huang J, Gui S, Chu X
doaj
Drug Induced Hypersensitivity and the HLA Complex
Pharmaceuticals, 2010 Drug-induced hypersensitivity reactions are of major concern and present a burden for national healthcare systems due to their often severe nature, high rate of hospital admissions and high mortality. They manifest with a wide range of symptoms and signs,
Munir Pirmohamed, Ana Alfirevic
doaj +1 more source
The Major Histocompatibility Complex in Transplantation
Journal of Transplantation, 2012 The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the ...
Marco Antonio Ayala García +3 more
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Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen. [PDF]
PLoS ONE, 2014 Superantigens (SAgs) are microbial toxins that cross-link T cell receptors with major histocompatibility class II (MHC-II) molecules leading to the activation of large numbers of T cells.
Kelcey G Patterson +5 more
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Blood ties: ABO is a trans-species polymorphism in primates [PDF]
, 2012 The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes responsible for A and B specificity in all species sequenced to date.
arxiv +1 more source
Interpreting BERT architecture predictions for peptide presentation by MHC class I proteins [PDF]
arXiv, 2021 The major histocompatibility complex (MHC) class-I pathway supports the detection of cancer and viruses by the immune system. It presents parts of proteins (peptides) from inside a cell on its membrane surface enabling visiting immune cells that detect non-self peptides to terminate the cell.
arxiv
Antigen processing and presentation in cancer immunotherapy
Journal for ImmunoTherapy of Cancer, 2020 Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy.
Maxwell Y Lee +3 more
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BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies [PDF]
arXiv, 2010 Gene-gene interactions have long been recognized to be fundamentally important to understand genetic causes of complex disease traits. At present, identifying gene-gene interactions from genome-wide case-control studies is computationally and methodologically challenging.
arxiv
A genome-wide survey of genetic variation in gorillas using reduced representation sequencing [PDF]
, 2013 All non-human great apes are endangered in the wild, and it is therefore important to gain an understanding of their demography and genetic diversity. To date, however, genetic studies within these species have largely been confined to mitochondrial DNA and a small number of other loci.
arxiv +1 more source
Contact map dependence of a T cell receptor binding repertoire [PDF]
arXiv, 2021 The T cell arm of the adaptive immune system provides the host protection against unknown pathogens by discriminating between host and foreign material. This discriminatory capability is achieved by the creation of a repertoire of cells each carrying a T cell receptor (TCR) specific to non-self antigens displayed as peptides bound to the major ...
arxiv